Correlation between the growth of uterine leiomyomata and estrogen and progesterone receptor content in needle biopsy specimens
Correlation between the growth of uterine leiomyomata and estrogen and progesterone receptor content in needle biopsy specimens
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DOI：
10.1016/s0015-0282(98)00300-8
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发表时间：
1998-11-01
影响因子：
6.7
通讯作者：
Ogita, S
中科院分区：
文献类型：
--
作者：
Ichimura, T;Kawamura, N;Ogita, S
目的：探讨穿刺活检标本中雌激素受体（ER）和孕激素受体（PR）含量与活检后子宫肌瘤生长的关系。设计：前瞻性临床研究。地点：大学教学医院。患者：31 名患有子宫肌瘤且月经周期正常的女性。干预措施：经宫颈子宫肌瘤穿刺活检 主要结果指标：分析组织学特征（平滑肌含量、ER和PR的免疫组化表达）与磁共振成像测量的最大肌瘤结节体积在12个月观察期内的增加百分比之间的关系。结果：子宫肌瘤组织中PR的免疫组化染色密度和强度均显示出显着差异。 与子宫肌瘤生长呈正相关。结论：子宫肌瘤的生长可以通过子宫肌瘤穿刺活检标本的组织学和免疫组织化学分析来确定。 （Fertil Steril(R) 1998；70:967-71。(C) 1998 年，美国生殖医学会。）。
Objective: To examine the relationship between estrogen receptor (ER) and progesterone receptor (PR) content in needle biopsy specimens and the growth of uterine leiomyomata after biopsy.Design: Prospective clinical study.Setting: University teaching hospital.Patient(s): Thirty-one women with uterine leiomyomata and a normal menstrual cycle.Intervention(s): Transcervical needle biopsy of uterine leiomyomata.Main Outcome Measure(s): The relationships between histologic features (smooth muscle content, immunohistochemical expression of ER and PR) and the percent increase over a 12-month observation period in the volume of the largest myoma nodule measured by magnetic resonance imaging were analyzed.Result(s): Both the density and intensity of immunohistochemical staining of PRs in uterine leiomyoma tissue showed significant positive correlation with leiomyoma growth.Conclusion(s): The growth of uterine leiomyomata can be determined by histologic and immunohistochemical analysis of needle biopsy specimens from uterine leiomyomata. (Fertil Steril(R) 1998;70:967-71. (C) 1998 by American Society for Reproductive Medicine.).