Genome-wide natural antisense transcription: coupling its regulation to its different regulatory mechanisms
Genome-wide natural antisense transcription: coupling its regulation to its different regulatory mechanisms
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DOI：
10.1038/sj.embor.7400857
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发表时间：
2006-12-01
期刊：
影响因子：
7.7
通讯作者：
Pilpel, Yitzhak
中科院分区：
文献类型：
--
作者：
Lapidot, Michal;Pilpel, Yitzhak
许多基因组位点在两条链上都含有转录单位，因此两个相反方向的转录本可以重叠。通常，一条链编码蛋白质，而另一条链的转录物是非编码的。这种天然反义转录本（NAT）可以负向调节缀合的有义转录本。 NAT 在许多物种中非常普遍，例如，大约 15% 的人类蛋白质编码基因具有相关的 NAT。 NAT 发挥作用的调节机制多种多样，控制其表达的手段也多种多样。在这里，我们回顾了目前对 NAT 功能及其机制基础的理解，这些理解是从个体基因案例和全基因组研究中收集到的。与此同时，我们调查了有关 NAT 转录调控的发现。最后，我们假设反义转录的调控可能适合其作用模式。根据该模型，观察到的 NAT 表达模式与其靶标之间的关系可能表明正在发挥作用的调节机制。
Many genomic loci contain transcription units on both strands, therefore two oppositely oriented transcripts can overlap. Often, one strand codes for a protein, whereas the transcript from the other strand is non-encoding. Such natural antisense transcripts (NATs) can negatively regulate the conjugated sense transcript. NATs are highly prevalent in a wide range of species-for example, around 15% of human protein-encoding genes have an associated NAT. The regulatory mechanisms by which NATs act are diverse, as are the means to control their expression. Here, we review the current understanding of NAT function and its mechanistic basis, which has been gathered from both individual gene cases and genome-wide studies. In parallel, we survey findings about the regulation of NAT transcription. Finally, we hypothesize that the regulation of antisense transcription might be tailored to its mode of action. According to this model, the observed relationship between the expression patterns of NATs and their targets might indicate the regulatory mechanism that is in action.