Hypoxic tumor microenvironment: Opportunities to develop targeted therapies.
Hypoxic tumor microenvironment: Opportunities to develop targeted therapies.
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DOI：
10.1016/j.biotechadv.2016.04.005
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发表时间：
2016-09
影响因子：
16
通讯作者：
Sant S
中科院分区：
文献类型：
--
作者：
Patel A;Sant S
近年来，人们对肿瘤生物学及周围微环境的认识有了长足的进步。实体肿瘤会产生含氧量低的区域，通常被称为缺氧区。这些缺氧区为开发靶向治疗提供了巨大的机会。缺氧并不是由于肿瘤生长失控而导致的细胞环境的随机副产品；相反，它是整个肿瘤生长和命运的一个不断演变的参与者。本文综述了针对肿瘤微环境中缺氧的药物治疗和递送系统的当前趋势和最新进展。在第一部分中，我们介绍了低氧微环境中重要的物理化学变化和激活的信号通路。然后是各种治疗策略，包括低氧敏感信号通路和开发低氧靶向药物输送系统的方法。
Recent few years have seen great progress in understanding tumor biology and surrounding microenvironment. Solid tumors create regions with low oxygen levels, generally termed as hypoxic regions. These hypoxic areas offer a tremendous opportunity to develop targeted therapies. Hypoxia is not a random by-product of cellular milieu due to uncontrolled tumor growth; rather it is a constantly evolving participant in overall tumor growth and fate. This article reviews current trends and recent advances in drug therapies and delivery systems targeting hypoxia in the tumor microenvironment. In the first part, we give an account of important physicochemical changes and signaling pathways activated in the hypoxic microenvironment. This is then followed by various treatment strategies including hypoxia-sensitive signaling pathways and approaches to develop hypoxia-targeted drug delivery systems.