Playing hide-and-seek with host macrophages through the use of mycobacterial cell envelope phthiocerol dinnycocerosates and phenolic glycolipids
Playing hide-and-seek with host macrophages through the use of mycobacterial cell envelope phthiocerol dinnycocerosates and phenolic glycolipids
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DOI：
10.3389/fcimb.2014.00173
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发表时间：
2014-12-01
影响因子：
5.7
通讯作者：
Astarie-Dequeker, Catherine
中科院分区：
文献类型：
--
作者：
Arbues, Ainhoa;Lugo-Villarino, Gean Carlo;Astarie-Dequeker, Catherine
分枝杆菌病原体，包括结核分枝杆菌（Mycobacterium tuberculosis），结核病（TB）的病原体，已经进化出逃避免疫系统以存活并定殖宿主的显著能力。其中最重要的逃避策略是这些杆菌寄生宿主巨噬细胞的能力，因为这些是对抗细胞内病原体的主要效应细胞，可用作长期细胞储库。分枝杆菌病原体利用一系列毒力因子操纵巨噬细胞功能以存活并建立感染。然而，直到最近，分枝杆菌细胞被膜脂质作为巨噬细胞破坏中的毒力因子的作用仍然难以捉摸。在这里，我们将专门解决所提出的作用，为phthiocerol dimycerosates（DIM）在居民巨噬细胞的反应和酚糖脂（PGL）的调节的招聘和表型传入巨噬细胞前体的感染部位的调制。我们将为这些脂质的潜在额外功能提供一个独特的视角，并强调进一步了解它们在结核病和其他分枝杆菌疾病发病机制中的作用的障碍和机会。
Mycobacterial pathogens, including Mycobacterium tuberculosis, the etiological agent of tuberculosis (TB), have evolved a remarkable ability to evade the immune system in order to survive and to colonize the host. Among the most important evasion strategies is the capacity of these bacilli to parasitize host macrophages, since these are major effector cells against intracellular pathogens that can be used as long-term cellular reservoirs. Mycobacterial pathogens employ an array of virulence factors that manipulate macrophage function to survive and establish infection. Until recently, however, the role of mycobacterial cell envelope lipids as virulence factors in macrophage subversion has remained elusive. Here, we will address exclusively the proposed role for phthiocerol dimycocerosates (DIM) in the modulation of the resident macrophage response and that of phenolic glycolipids (PGL) in the regulation of the recruitment and phenotype of incoming macrophage precursors to the site of infection. We will provide a unique perspective of potential additional functions for these lipids, and highlight obstacles and opportunities to further understand their role in the pathogenesis of TB and other mycobacterial diseases.