Secondary hypoxia following moderate fluid percussion brain injury in rats exacerbates sensorimotor and cognitive deficits
Secondary hypoxia following moderate fluid percussion brain injury in rats exacerbates sensorimotor and cognitive deficits
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DOI：
10.1089/neu.1999.16.1035
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发表时间：
1999-11-01
影响因子：
4.2
通讯作者：
Green, EJ
中科院分区：
文献类型：
--
作者：
Bramlett, HM;Dietrich, WD;Green, EJ
人类头部创伤通常与导致二次缺氧损伤的呼吸系统问题有关。为了记录在创伤性脑损伤（TBI）的已建立模型中继发性缺氧的行为后果，使插管麻醉的动物经受液压冲击（FP）损伤（1.87-2.17 atm），随后是30分钟的常氧（TBI-NO，n = 10）或缺氧（TBI-HY，n = 11; pO（2）= 30-40 mm Hg）气体水平。假手术组动物（n = 19）接受除实际创伤外的所有操作。在FP损伤后沿着3天开始对动物进行各种感觉运动任务测试，并在创伤后第22天至第29天进行认知测试。与仅接受创伤的那些动物相比，继发性低氧损伤加重了在横梁行走时的感觉运动缺陷。与单独FP损伤相比，在TBI-HY组中还观察到隐藏平台任务中的认知障碍。这些数据表明，继发性缺氧损伤加重了TBI后的感觉运动和认知缺陷。本研究提供了直接证据，表明脑外伤后缺氧的发生率可能会导致经历缺氧条件的头部受伤患者亚群的神经功能缺陷增加，从而进一步加强对这些事件的严格监测。
Human head trauma is frequently associated with respiratory problems resulting in secondary hypoxic insult. To document the behavioral consequences of secondary hypoxia in an established model of traumatic brain injury (TBI), intubated anesthetized animals were subjected to fluid percussion (FP) injury (1.87-2.17 atm) followed by 30 min of either normoxic (TBI-NO, n = 10) or hypoxic (TBI-HY, n = 11; pO(2) = 30-40 mm Hg) gas levels. Sham animals (n = 19) underwent all manipulations except for the actual trauma. Animals were tested on various sensorimotor tasks beginning 3 days after FP injury along with cognitive testing on days 22 through 29 posttrauma, The secondary hypoxic insult exacerbated the sensorimotor deficits on beam-walking compared to those animals only receiving trauma. Cognitive impairments were also observed in the TBI-HY group in the hidden platform task compared to FP injury alone. These data indicate that a secondary hypoxic insult exacerbates both sensorimotor and cognitive deficits after TBI, This study provides direct evidence that incidences of hypoxia after brain trauma may potentially result in an increase in neurological deficits for the subpopulation of head injured patients undergoing hypoxic conditions further warranting strict monitoring of these events.