The Influence of Sedentary Behavior on Cancer Risk: Epidemiologic Evidence and Potential Molecular Mechanisms
The Influence of Sedentary Behavior on Cancer Risk: Epidemiologic Evidence and Potential Molecular Mechanisms
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DOI：
10.1007/s13668-019-0263-4
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发表时间：
2019-09-01
影响因子：
4.9
通讯作者：
Leitzmann, Michael F.
中科院分区：
文献类型：
--
作者：
Jochem, Carmen;Wallmann-Sperlich, Birgit;Leitzmann, Michael F.
久坐行为是几种癌症的一个新的危险因素。在这里，我们回顾了当前有关久坐行为和癌症风险的流行病学证据，并总结了潜在的潜在分子机制。最近的发现与低久坐行为相比，高久坐行为与结肠癌风险增加28-44%、乳腺癌风险增加8-17%有关。增加28-36%子宫内膜癌的风险。对于其他癌症部位，目前的证据不足，主要是由于现有研究数量稀少。潜在的潜在生物学机制将长期久坐行为与癌症风险增加联系起来，包括代谢功能障碍、性激素循环水平的改变和低度系统性慢性inflammation.Summary长期久坐行为与结肠癌、乳腺癌和子宫内膜癌呈正相关。对于其他类型的癌症，目前的证据是不确定的。基本的生物学机制知之甚少，需要成为未来研究的组成部分。
Purpose of Review Sedentary behavior is an emerging risk factor for several cancers. Here, we review the current epidemiologic evidence on sedentary behavior and cancer risk and summarize potential underlying molecular mechanisms.Recent Findings High compared to low sedentary behavior is associated with a 28-44% increased risk of colon cancer, a 8-17% increased risk of breast cancer, and a 28-36% increased risk of endometrial cancer. For other cancer sites, the current evidence is insufficient, mainly due to sparse numbers of available studies. Potential underlying biologic mechanisms linking prolonged sedentary behavior to increased cancer risk include metabolic dysfunction, alterations in circulating levels of sex hormones, and low-grade systemic chronic inflammation.Summary Prolonged sedentary behavior is positively related to cancers of the colon, breast, and endometrium. For other cancer types, the current evidence is inconclusive. Underlying biological mechanisms are poorly understood and need to be an integral part of future research.