Abnormal cortical thickness alterations in fetal alcohol spectrum disorders and their relationships with facial dysmorphology.
Abnormal cortical thickness alterations in fetal alcohol spectrum disorders and their relationships with facial dysmorphology.
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DOI：
10.1093/cercor/bhr193
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发表时间：
2012-05
期刊：
影响因子：
3.7
通讯作者：
Yaling Yang;Florence F. Roussotte;E. Kan;K. Sulik;S. Mattson;E. Riley;K. Jones;C. Adnams;P. May-P.-M
中科院分区：
文献类型：
--
作者：
Yaling Yang;Florence F. Roussotte;E. Kan;K. Sulik;S. Mattson;E. Riley;K. Jones;C. Adnams;P. May-P.-M
从胎儿酒精谱系障碍（FASD）个体的脑结构成像研究中积累的证据支持产前酒精暴露与脑形态缺陷之间的联系。尽管全球和区域体积减少似乎相对强劲，但酒精暴露对皮质厚度的影响以及与面部畸形的关系尚不清楚。使用FreeSurfer检查了从3个地点收集的69名FASD儿童和青少年以及58名未暴露对照组的结构磁共振成像数据，以检测FASD患者全脑皮层厚度的变化及其与面部畸形的关系。在控制大脑大小的情况下，FASD患者在额叶、颞叶和顶叶区域的皮质明显比对照组厚。在这三个部位内进行的分析进一步揭示了左侧额叶下皮层的显著组间差异。此外，额下厚度的增加与睑裂长度的减少显著相关。与先前的报道一致，本研究的发现支持皮层厚度的区域性增加作为FASD大脑发育中断的生物标志物。此外，厚度和畸形测量之间的显著关联表明，大脑异常的严重程度可能反映在面部。
Accumulating evidence from structural brain imaging studies on individuals with fetal alcohol spectrum disorder (FASD) has supported links between prenatal alcohol exposure and brain morphological deficits. Although global and regional volumetric reductions appear relatively robust, the effects of alcohol exposure on cortical thickness and relationships with facial dysmorphology are not yet known. The structural magnetic resonance imaging data from 69 children and adolescents with FASD and 58 nonexposed controls collected from 3 sites were examined using FreeSurfer to detect cortical thickness changes across the entire brain in FASD and their associations with facial dysmorphology. Controlling for brain size, subjects with FASD showed significantly thicker cortices than controls in several frontal, temporal, and parietal regions. Analyses conducted within site further revealed prominent group differences in left inferior frontal cortex within all 3 sites. In addition, increased inferior frontal thickness was significantly correlated with reduced palpebral fissure length. Consistent with previous reports, findings of this study are supportive of regional increases in cortical thickness serving as a biomarker for disrupted brain development in FASD. Furthermore, the significant associations between thickness and dysmorphic measures suggest that the severity of brain anomalies may be reflected by that of the face.