Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer
Overexpression of cyclooxygenase-2 correlates with advanced stages of colorectal cancer
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DOI：
10.1111/j.1572-0241.2002.05625.x
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发表时间：
2002-04
影响因子：
9.8
通讯作者：
Hong Zhang;Xiao-Feng Sun
中科院分区：
文献类型：
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作者：
Hong Zhang;Xiao-Feng Sun
目的：探讨环氧化酶2（cyclooxygenase-2，考克斯-2）与结直肠癌病理特征及生存期的关系.方法：采用免疫组化法检测112例结直肠癌组织中考克斯-2的表达，其中64例为正常结直肠组织，16例为结直肠癌区域淋巴结转移组织.结果：考克斯-2的表达频率和强度从正常组织（17%）到原发性肿瘤（72%）和转移性肿瘤（100%）均显著增加。Dukes' A、B、C和D肿瘤中考克斯-2的表达分别为25%、74%、78%和67%（p = 0.005），与增殖活性呈正相关（p = 0.003）。考克斯-2在结肠肿瘤中的表达率为80%，在直肠肿瘤中的表达率为60%（p = 0.03）。考克斯-2的表达与结肠肿瘤的分化程度呈正相关（p = 0.04）。COX-2表达与患者年龄、性别、肿瘤生长方式、细胞凋亡及患者生存期均无相关性（p > 0.05）。结论：考克斯-2表达从正常细胞到肿瘤原发灶及转移灶均有上调，且与肿瘤的增殖活性、肿瘤部位、Dukes'分期及分化程度有关。这些结果进一步支持了考克斯-2可能参与结直肠癌的发生和发展的证据。
OBJECTIVE:We aimed to investigate the associations of cyclooxygenase-2 (COX-2) with pathological features and survival in patients with colorectal cancer.METHODS:The expression of COX-2 was examined by immunohistochemistry in 112 primary colorectal cancers, with 64 samples from the corresponding normal mucosa and 16 metastases in the regional lymph nodes of patients with colorectal cancer. The associations of COX-2 expression with clinicopathological features, including survival, were analyzed.RESULTS:The frequency and intensity of COX-2 staining were remarkably increased from the normal samples (17%) to the primary tumors (72%) and to the metastases (100%). Expressions of COX-2 were 25%, 74%, 78%, and 67% in Dukes’ A, B, C, and D tumors, respectively (p = 0.005), and positively related to proliferative activity (p = 0.003). COX-2 expressions were 80% in colonic tumors and 60% in rectal tumors (p = 0.03). The expression of COX-2 was positively related to the better differentiated tumors in the colon (p = 0.04). We were unable to find any relationship of COX-2 with patient age, sex, tumor growth pattern, apoptosis, and patient survival (p > 0.05).CONCLUSION:We found that the expression of COX-2 was upregulated from normal cells to primary tumors and to metastases, and related to proliferative activity, tumor location, Dukes’ stage, and differentiation. These results further support the evidence that COX-2 may be involved in tumorigenesis and development of colorectal cancer.