Two novel pyrrole-imidazole alkaloids from the Mediterranean sponge Agelas oroides
Two novel pyrrole-imidazole alkaloids from the Mediterranean sponge Agelas oroides
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DOI：
10.1016/s0040-4039(00)01764-0
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发表时间：
2000-12-09
影响因子：
1.8
通讯作者：
Taglialatela-Scafati, O
中科院分区：
文献类型：
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作者：
Fattorusso, E;Taglialatela-Scafati, O
从地中海海绵Agelas oroides中分离得到两个新的吡咯-咪唑类生物碱cyclooroidin（7）和taurodispacamide A（8），并通过光谱数据确定了它们的结构。虽然这两种生物碱都可以被认为是已知的oroidin（1）的C11 N5骨架的衍生物，但值得注意的是，cyclooroidin（7）具有前所未有的N1/C9连接。牛磺酰双己酰胺A（8）在离体豚鼠回肠上显示出良好的抗组胺活性。(C)2000爱思唯尔科技有限公司版权所有。
The novel pyrrole-imidazole alkaloids cyclooroidin (7) and taurodispacamide A (8) have been isolated from the Mediterranean sponge Agelas oroides, and their structures established from spectroscopic data. Although both these alkaloids may be conceived as derivatives of the C11N5 skeleton of the known oroidin (1), remarkably cyclooroidin (7) possesses the unprecedented N1/C9 connection. Tauro-dispacamide A (8) exhibited a good antihistaminic activity, tested on the isolated guinea pig ileum. (C) 2000 Elsevier Science Ltd. All rights reserved.