The relationship between the Met allele of the BDNF Val66Met polymorphism and impairments in decision making under ambiguity in patients with obsessive-compulsive disorder
The relationship between the Met allele of the BDNF Val66Met polymorphism and impairments in decision making under ambiguity in patients with obsessive-compulsive disorder
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DOI：
10.1111/j.1601-183x.2011.00687.x
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发表时间：
2011-07-01
影响因子：
2.5
通讯作者：
Correa, H.
中科院分区：
文献类型：
--
作者：
da Rocha, F. F.;Malloy-Diniz, L.;Correa, H.
脑源性神经营养因子（BDNF）基因与包括血清素在内的神经递质系统有着重要的联系，并且似乎在情绪决策中发挥着重要作用。决策障碍是强迫症（OCD）等精神疾病的重要特征。我们探讨决策和BDNF Val 66 Met多态性之间的联系，这导致BDNF活性的降低，在白人强迫症患者的样本。我们使用爱荷华州赌博任务（IGT）来衡量122名强迫症患者的决策。采用耶鲁-布朗强迫量表、贝克抑郁量表、贝克焦虑量表和瑞文推理测验对所有患者进行评估。患者还进行了连续性能任务（CPT-II）和连线测试（TMT）。我们将Met等位基因携带者分组，因为这些基因以显性方式起作用。Met-allele携带者在IGT的两个半部分上表现出低性能（前半部分- F =-2.51，df = 120，P = 0.01;后半部分- F =-2.32，df = 120，P = 0.02）。然而，逻辑回归分析显示Met等位基因的影响似乎仅限于IGT的前半部分[前半部分-β = 0.55，df = 1，P < 0.01，比值比（OR）= 5.62;后半部分-β = 0.32，df = 1，P = 0.15，OR = 2.30]。在用于评估与背外侧前额叶皮层相关的执行功能的测试中没有观察到差异（TMT和CPT-II，df = 120，P > 0.05）。金属等位基因损伤可能只与在模棱两可的条件下做出的决定有关。TMT和CPT-II的无效结果可能与强迫症相关的眶额皮质功能障碍有关。
Brain-derived neurotrophic factor (BDNF) gene has an important link to neurotransmitter systems, including serotonin, and seems to play a major role in emotional decision making. Impairment of decision making is an important feature of psychiatric disorders such as obsessive-compulsive disorder (OCD). We explore the link between decision making and the BDNF Val66Met polymorphism, which results in a reduction of BDNF activity, in a sample of Caucasian OCD patients. We used the Iowa Gambling Task (IGT) to measure decision making in 122 OCD patients. All patients were assessed using the Yale-Brown Obsessive-Compulsive Scale, the Beck Depression Inventory, the Beck Anxiety Inventory and the Raven Progressive Matrices. Patients also performed the Continuous Performance Task (CPT-II) and the Trail Making Test (TMT). We grouped Met-allele carriers because these act in a dominant way. Met-allele carries exhibited low performance on both halves of the IGT (first half - F = -2.51, df = 120, P = 0.01; second half - F = -2.32, df = 120, P = 0.02). However, logistic regression analyses showed that the influence of the Met allele seemed to be restricted to the first half of the IGT [first half - beta = 0.55, df = 1, P < 0.01, odds ratio (OR) = 5.62; second half - beta = 0.32, df = 1, P = 0.15, OR = 2.30]. No differences were observed in tests used to evaluate executive functions associated with the dorsolateral prefrontal cortices (TMT and CPT-II, df = 120, P > 0.05 for both). Met-allele impairment may only be related to decisions made under ambiguous conditions. The null results involving TMT and CPT-II are possibly related to the dysfunction of the orbitofrontal cortices that is associated with OCD.