Sleep apnoea is a risk factor for severe COVID-19.
Sleep apnoea is a risk factor for severe COVID-19.
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DOI：
10.1136/bmjresp-2020-000845
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发表时间：
2021-01
影响因子：
4.1
通讯作者：
Ollila HM
中科院分区：
文献类型：
--
作者：
Strausz S;Kiiskinen T;Broberg M;Ruotsalainen S;Koskela J;Bachour A;FinnGen;Palotie A;Palotie T;Ripatti S;Ollila HM
阻塞性睡眠呼吸暂停与较高的体重指数、糖尿病、年龄和男性相关，这些都是严重新冠肺炎的危险因素。我们的目的是研究阻塞性睡眠呼吸暂停综合征是新冠肺炎感染还是严重新冠肺炎的独立危险因素。OSA诊断和新冠肺炎感染是从参与FinnGen研究的个人的出院情况、死因和传染病登记中提取的(n=260 405)。重症新冠肺炎被定义为需要住院治疗的新冠肺炎。采用多因素Logistic回归模型检验关联性。新冠肺炎或阻塞性睡眠呼吸暂停综合征的并存被选为协变量。我们对之前的研究进行了荟萃分析。我们确定了445名新冠肺炎患者，其中38人(8.5%)患有阻塞性睡眠呼吸暂停，其中19人(20.9%)住院治疗。与新冠肺炎入院相关的阻塞性睡眠呼吸暂停与年龄、性别、体重指数和合并症无关(p-未调整=5.13x10−5，OR=2.93(95%CI1.02至8.39)，p-调整=0.045)。阻塞性睡眠呼吸暂停综合征与感染新冠肺炎的风险无关(p=0.25)。对阻塞性睡眠呼吸暂停与重度新冠肺炎的Meta分析显示，15835例新冠肺炎阳性对照和1294例阻塞性睡眠呼吸暂停伴重度新冠肺炎患者有关联(OR=2.37(95%1.14~4.95，p=0.021))。患有阻塞性睡眠呼吸暂停综合症和没有阻塞性睡眠呼吸暂停综合症的患者感染新冠肺炎的风险是相同的。相比之下，在新冠肺炎阳性的患者中，阻塞性睡眠呼吸暂停与更高的住院风险相关。我们的发现与早期的工作一致，并建议阻塞性睡眠呼吸暂停综合征是严重新冠肺炎的独立危险因素。
Obstructive sleep apnoea (OSA) is associated with higher body mass index (BMI), diabetes, older age and male gender, which are all risk factors for severe COVID-19. We aimed to study if OSA is an independent risk factor for COVID-19 infection or for severe COVID-19. OSA diagnosis and COVID-19 infection were extracted from the hospital discharge, causes of death and infectious diseases registries in individuals who participated in the FinnGen study (n=260 405). Severe COVID-19 was defined as COVID-19 requiring hospitalisation. Multivariate logistic regression model was used to examine association. Comorbidities for either COVID-19 or OSA were selected as covariates. We performed a meta-analysis with previous studies. We identified 445 individuals with COVID-19, and 38 (8.5%) of them with OSA of whom 19 out of 91 (20.9%) were hospitalised. OSA associated with COVID-19 hospitalisation independent from age, sex, BMI and comorbidities (p-unadjusted=5.13×10−5, OR-adjusted=2.93 (95% CI 1.02 to 8.39), p-adjusted=0.045). OSA was not associated with the risk of contracting COVID-19 (p=0.25). A meta-analysis of OSA and severe COVID-19 showed association across 15 835 COVID-19 positive controls, and n=1294 patients with OSA with severe COVID-19 (OR=2.37 (95% 1.14 to 4.95), p=0.021). Risk for contracting COVID-19 was the same for patients with OSA and those without OSA. In contrast, among COVID-19 positive patients, OSA was associated with higher risk for hospitalisation. Our findings are in line with earlier works and suggest OSA as an independent risk factor for severe COVID-19.
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DOI：
10.15585/mmwr.mm6915e3
发表时间：
2020-04-17
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garg S;Kim L;Whitaker M;O'Halloran A;Cummings C;Holstein R;Prill M;Chai SJ;Kirley PD;Alden NB;Kawasaki B;Yousey-Hindes K;Niccolai L;Anderson EJ;Openo KP;Weigel A;Monroe ML;Ryan P;Henderson J;Kim S;Como-Sabetti K;Lynfield R;Sosin D;Torres S;Muse A;Bennett NM;Billing L;Sutton M;West N;Schaffner W;Talbot HK;Aquino C;George A;Budd A;Brammer L;Langley G;Hall AJ;Fry A
通讯作者：
Fry A
影响因子：
8.2
作者：
Cariou, Bertrand;Hadjadj, Samy;Gourdy, Pierre
通讯作者：
Gourdy, Pierre
影响因子：
76.2
作者：
Fan, Eddy;Beitler, Jeremy R.;Brodie, Daniel
通讯作者：
Brodie, Daniel
影响因子：
44.5
作者：
Apicella, Matteo;Campopiano, Maria Cristina;Prato, Stefano Del
通讯作者：
Prato, Stefano Del
影响因子：
24.3
作者：
Strausz, Satu;Ruotsalainen, Sanni;Ripatti, Samuli
通讯作者：
Ripatti, Samuli