Comparative growth of SJL/J lymphomas in irradiated and normal SJL/J mice: cell cycle distribution and tumor cell quantification.
Comparative growth of SJL/J lymphomas in irradiated and normal SJL/J mice: cell cycle distribution and tumor cell quantification.
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受辐射和正常 SJL/J 小鼠中 SJL/J 淋巴瘤的生长比较：细胞周期分布和肿瘤细胞定量。
DOI：
10.1093/jnci/75.5.877
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Lerman,SP
中科院分区：
文献类型：
--
作者：
RosloniecJr,EF;Gottlieb,C;Butch,AW;Lerman,SP
肿瘤细胞的流式细胞术和生物学定量显示，650拉德γ-辐射1天前静脉注射H-2DS阴性淋巴瘤细胞到SJL/J小鼠导致约4倍（第3天）至12倍（第7天）的淋巴器官的肿瘤细胞含量减少相比，在未照射的小鼠。在700拉德γ射线照射的F1小鼠中观察到的肿瘤生长（第7天）比未照射的（SJL/J × CBA/J）F1小鼠中的肿瘤生长少约1.6倍。在照射和未照射小鼠中，细胞周期S期的肿瘤细胞分布在第3、5和7天相当。尽管在辐照的SJL/J小鼠中约26%的脾肿瘤细胞在第5天和第7天处于S期，但脾肿瘤细胞含量在此期间并未增加。数据表明，早期（第3天之前）和晚期（第5天之后）事件是导致受辐射小鼠肿瘤生长减少的原因。
Flow cytometric and biological quantification of tumor cells revealed that 650 rad gamma-radiation 1 day prior to iv injection of H-2DSnegative lymphoma cells into SJL/J mice resulted in approximately a fourfold (day 3) to twelvefold (day 7) decrease in the tumor cell content of lymphoid organs as compared to that in unirradiated mice. Approximately 1.6-fold less tumor growth was noted (day 7) in 700-rad gamma-irradiated as compared to growth in unirradiated (SJL/J × CBA/J)F1mice. Distributions of tumor cells in S-phase of the cell cycle were comparable at days 3, 5, and 7 in irradiated and unirradiated mice. Although approximately 26% of splenic tumor cells were in S-phase at days 5 and 7 in irradiated SJL/J mice, splenic tumor cell content did not increase during this time period. The data indicate that early (prior to day 3) and late (after day 5) events are responsible for decreased tumor growth in irradiated mice.