10-phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine-derived fungus Spicaria elegans
10-phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine-derived fungus Spicaria elegans
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DOI：
10.1021/np050201m
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发表时间：
2006-06-23
影响因子：
5.1
通讯作者：
Liu, Hongbing
中科院分区：
文献类型：
--
作者：
Liu, Rui;Gu, Qianqun;Liu, Hongbing
从海洋真菌Spicaria elegans中分离得到3个新的10-苯基-[12]-细胞松弛素Z（7）、Z（8）和Z（9）（1-3），以及两个已知的类似物细胞松弛素E（4）和K（5）。这是迄今为止第二次报道细胞松弛素含有12元大环。用光谱方法确定了三种新的细胞松弛素的结构，并用改进的Mosher方法首次确定了它们的绝对构型。采用MTT法检测5种细胞松弛素对P388和A-549细胞的细胞毒作用。
The three new 10-phenyl-[12]-cytochalasins Z(7), Z(8), and Z(9) (1-3), together with two known analogues, cytochalasins E ( 4) and K ( 5), were isolated from the marine-derived fungus Spicaria elegans. This is only the second report to date that cytochalasins contain a 12-membered macrocyclic ring. The structures of the three new cytochalasins were elucidated by spectroscopic methods, and their absolute configurations were determined for the first time by the modified Mosher's method. All five cytochalasins were evaluated for their cytotoxic effects on P388 and A-549 cell lines by the MTT method.