Chlamydia trachomatis infections in female military recruits
Chlamydia trachomatis infections in female military recruits
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DOI：
10.1056/nejm199809103391105
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发表时间：
1998-09-10
影响因子：
158.5
通讯作者：
Quinn, TC
中科院分区：
文献类型：
--
作者：
Gaydos, CA;Howell, MR;Quinn, TC
背景女性无症状生殖器沙眼衣原体感染可导致盆腔炎、不孕症和宫外孕。方法1996年1月至1997年12月，对来自美国50个州的13，204名新入伍的美国陆军女性进行了尿标本连接酶链反应筛查衣原体。沙眼感染通过问卷调查获得有关潜在危险因素的信息。多因素分析，我们确定了筛选programmes.Results衣原体感染的总患病率为9.2%，与12.2%的17岁的新兵中的峰值。在来自南部五个州的新兵中，患病率为15%或更高。以下风险因素与衣原体感染独立相关：有过阴道性交（感染的比值比，5.9），年龄在25岁或以下（优势比，3.0），黑人（优势比，3.4），在过去的90天内有一个以上的性伴侣（优势比，1.4），在过去的90天内有一个新的合作伙伴（比值比，1.3），在过去90天内有一个不总是使用避孕套的伴侣（比值比，1.4），和曾经有过性传播疾病（比值比，1.2）。对25岁或25岁以下的受试者（占我们样本的87.9%）进行筛查，将发现95.3%的感染妇女。在女性新兵中，衣原体感染的流行率很高。一个控制程序，筛选女性新兵谁是25岁或以下的尿液DNA扩增检测有可能减少感染，传播和衣原体感染的后遗症。（N Engl J Med 1998;339：739-44.）(C)1998年，马萨诸塞州医学会。
Background. Asymptomaticgenital Chlamydia trachomatis infections in women can lead to pelvic inflammatory disease, infertility, and ectopic pregnancy. To design a chlamydia-control program, we conducted a large survey of women in the U.S. military.Methods From January 1996 through December 1997, urine samples from 13,204 new female U.S. Army recruits from 50 states were screened by ligase chain reaction for C. trachomatis infection. Information on potential risk factors was obtained by questionnaire. With multivariate analysis, we identified criteria for a screening program.Results The overall prevalence of chlamydial infection was 9.2 percent, with a peak of 12.2 percent among the 17-year-old recruits. The prevalence was 15 percent or more among the recruits from five southern states. The following risk factors were independently associated with chlamydial infection: having ever had vaginal sex (odds ratio for infection, 5.9), being 25 years of age or less (odds ratio, 3.0), being black (odds ratio, 3.4), having had more than one sex partner in the previous 90 days (odds ratio, 1.4), having had a new partner in the previous 90 days (odds ratio, 1.3), having had a partner in the previous 90 days who did not always use condoms (odds ratio, 1.4), and having ever had a sexually transmitted disease (odds ratio, 1.2). A screening program for subjects 25 years of age or less (87.9 per cent of our sample) would have identified 95.3 percent of the infected women.Conclusions. Among female military recruits, the prevalence of chlamydial infection is high. A control program that screens female recruits who are 25 years old or younger with urine DNA-amplification assays has the potential to reduce infection, transmission, and the sequelae of chlamydial infection. (N Engl J Med 1998;339:739-44.) (C) 1998, Massachusetts Medical Society.