Biochemistry of uridine in plasma.
Biochemistry of uridine in plasma.
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DOI：
10.1016/j.cca.2011.06.006
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发表时间：
2011-09
期刊：
影响因子：
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通讯作者：
Tetsuya Yamamoto;H. Koyama;Masafumi Kurajoh;T. Shoji;Z. Tsutsumi;Y. Moriwaki
中科院分区：
文献类型：
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作者：
Tetsuya Yamamoto;H. Koyama;Masafumi Kurajoh;T. Shoji;Z. Tsutsumi;Y. Moriwaki
尿苷是一种嘧啶核苷，在RNA、糖原和生物膜的合成中起着至关重要的作用。在人类中，尿苷在血浆中的含量比其他嘌呤和嘧啶核苷要高得多，因此它可能被用于内源性嘧啶的合成。尿苷对多种器官有或没有疾病，如生殖器官、中枢和外周神经系统以及肝脏都有许多生物学效应。此外，在临床情况下，它被用作抢救剂，以防止5-氟尿嘧啶的不良影响。由于尿苷的生物学作用可能与其血浆浓度有关，因此检查影响该浓度的因素是很重要的。与尿苷浓度升高相关的因素包括：ATP消耗增加，通过糖生成增加尿苷二磷酸(UDP)-葡萄糖消耗，通过核苷转运途径抑制细胞对尿苷的摄取，增加肠道吸收，以及增加5-磷酸核糖-1-焦磷酸和尿素合成。相反，降低尿苷血浆浓度的因素与细胞通过核苷转运途径加速尿苷摄取和减少嘧啶合成有关。
Uridine is a pyrimidine nucleoside that plays a crucial role in synthesis of RNA, glycogen, and biomembrane. In humans, uridine is present in plasma in considerably higher quantities than other purine and pyrimidine nucleosides, thus it may be utilized for endogenous pyrimidine synthesis. Uridine has a number of biological effects on a variety of organs with or without disease, such as the reproductive organs, central and peripheral nervous systems, and liver. In addition, it is used in clinical situations as a rescue agent to protect against the adverse effects of 5-fluorouracil. Since the biological actions of uridine may be related to its plasma concentration, it is important to examine factors that have effects on that concentration. Factors associated with an increase in plasma concentration of uridine include enhanced ATP consumption, enhanced uridine diphosphate (UDP)-glucose consumption via glycogenesis, inhibited uridine uptake by cells via the nucleoside transport pathway, increased intestinal absorption, and increased 5-phosphribosyl-1-pyrophosphate and urea synthesis. In contrast, factors that decrease the plasma concentration of uridine are associated with accelerated uridine uptake by cells via the nucleoside transport pathway and decreased pyrimidine synthesis.