Ligands and receptors of lung surfactant proteins SP-A and SP-D
Ligands and receptors of lung surfactant proteins SP-A and SP-D
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DOI：
10.2741/4168
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发表时间：
2013-06-01
影响因子：
3.1
通讯作者：
Sim, Robert B.
中科院分区：
文献类型：
--
作者：
Jakel, Anne;Qaseem, Asif S.;Sim, Robert B.
表面活性蛋白A（SP-A）和表面活性蛋白D（SP-D）是钙依赖性的含胶原凝集素，也称为胶原凝集素，其在表面活性剂稳态和肺免疫中起重要作用。SP-A和SP-D在免疫防御中的作用是公认的。已知它们与侵入肺部的一系列微生物病原体结合，并靶向它们以供驻留的肺泡巨噬细胞吞噬清除。它们还参与凋亡和坏死细胞的清除以及随后肺部炎症的消退。迄今为止，SP-A和SP-D与各种免疫细胞相互作用的分子机制知之甚少。尽管总体结构相似，SP-A和SP-D在与微生物和宿主细胞的表面分子的相互作用中显示出许多功能差异。本文综述了目前已知与SP-A和SP-D相互作用的配体和受体的研究进展。
Surfactant Protein A (SP-A) and D (SP-D) are calcium-dependent collagen-containing lectins, also called collectins, which play a significant role in surfactant homeostasis and pulmonary immunity. The role of SP-A and SP-D in immune defence is well-established. They are known to bind to a range of microbial pathogens that invade the lungs and target them for phagocytic clearance by resident alveolar macrophages. They are also involved in the clearance of apoptotic and necrotic cells and subsequent resolution of pulmonary inflammation. To date, the molecular mechanisms by which SP-A and SP-D interact with various immune cells are poorly understood. In spite of overall structural similarity, SP-A and SP-D show a number of functional differences in their interaction with surface molecules of microorganisms and host cells. The aim of this review is to provide an overview of the current knowledge of ligands and receptors that are known to interact with SP-A and SP-D.