A Qualitative and Quantitative Morphologic Study of Peyer's Patches of the Mouse
A Qualitative and Quantitative Morphologic Study of Peyer's Patches of the Mouse
复制标题
小鼠派尔氏集结的定性和定量形态学研究
DOI：
10.1679/aohc1950.40.407
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发表时间：
1977
影响因子：
--
通讯作者：
Takashi Ito
中科院分区：
文献类型：
--
作者：
K. Abe;Takashi Ito
光镜下对成年小鼠Peyer斑块进行形态学观察。斑块在地形上分为四个部分：生发中心、卵泡区、卵泡旁区和穹窿区。生发中心由光区和暗区组成。滤泡区围绕生发中心，特别是有一个顶极指向粘膜表面的光区。滤泡旁区包围滤泡区，含有高内皮的毛细血管后小静脉。穹窿区位于卵泡区上方。穹顶区上皮浸润大量淋巴细胞。在数量上，生发中心、卵泡面积和卵泡旁面积在体积上几乎相似（约占30%），圆顶面积只占很小的一部分（约占10%）。小淋巴细胞密度在卵泡区最高，在生发中心最低。在斑块中全部小淋巴细胞中，有8.4%包含在生发中心；滤泡区占58.2%；滤泡旁区占26.7%；3.8%在穹顶区域。上皮内小淋巴细胞在穹窿中的数量几乎是绒毛中的两倍。在穹窿中，几乎一半的上皮内淋巴细胞位于上皮细胞的核水平以上，而在绒毛中，7.3%的上皮内淋巴细胞位于核水平以上。结果表明，Peyer路径的功能结构与周围淋巴组织相似。
Peyer's patches of adult mice were morphologically studied by light microscopy.The patch is topographically divided into four portions: germinal center, follicular area, parafollicular area and dome area. The germinal center consists of light and dark zones. The follicular area surrounds the germinal center, especially the light zone which has an apical pole directed toward the mucosal surface. The parafollicular area surrounds the follicular area and contains postcapillary venules with high endothelium. The dome area is situated just above the follicular area. The epithelium over the dome area is infiltrated with numerous lymphocytes.Quantitatively, the germinal center, follicular area and parafollicular area are almost similar in volume (about 30%) and the dome area constitutes only a small portion (about 10%). The density of small lymphocytes is highest in the follicular area and lowest in the germinal center. Out of the total small lymphocytes in the patch, 8.4% are included in the germinal center; 58.2% in the follicular area; 26.7% in the parafollicular area; and 3.8% in the dome area. Intraepithelial small lymphocytes are almost twice as abundant in the dome as in the villi. In the dome, almost half the intraepithelial lymphocytes are above the nuclear level of the epithelial cells, whereas in the villi 7.3% of intraepithelial lymphocytes are above the nuclear level.The results suggest that the functional structure of the Peyer's path is similar to that of peripheral lymphatic tissues.