Insights into endocrine-immunological disturbances in autoimmunity and their impact on treatment.
Insights into endocrine-immunological disturbances in autoimmunity and their impact on treatment.
复制标题
DOI：
10.1186/ar2630
复制
发表时间：
2009
影响因子：
4.9
通讯作者：
Straub RH
中科院分区：
文献类型：
--
作者：
Cutolo M;Straub RH
The neuroendocrine immune (NEI) system is regarded as a fundamental network for the maintenance of health status (homeostasis), and it plays an important role in several systemic diseases, including autoimmune disorders. Among the major players of NEI pathways are steroid hormones of the adrenal (cortisol) and gonadal glands (sex hormones), neurohormones such as melatonin, and more recently the vitamin D endocrine system. Estrogens, melatonin and chronic stress (inducing decreased adrenal glucocorticoid release over a long time) strongly modulate the NEI system and stimulate the immune response. The vitamin D endocrine system is regarded as a potential immunosuppressive factor. Consequently, estrogens (especially in patients affected by B-cell-driven immunity) and melatonin should be avoided, and glucocorticoids (as replacement therapy) and vitamin D are allowed in the treatment of autoimmunity.
登录
查看更多内容
影响因子：
13.6
作者：
Cutolo, Maurizio;Otsa, Kati;Seriolo, Bruno
通讯作者：
Seriolo, Bruno
影响因子：
4.4
作者：
Boonstra, A;Barrat, FJ;O'Garra, A
通讯作者：
O'Garra, A
影响因子：
4.3
作者：
Adorini, L
通讯作者：
Adorini, L
影响因子：
5.5
作者：
Cutolo, M.;Capellino, S.;Straub, R. H.
通讯作者：
Straub, R. H.
DOI：
10.1111/j.1749-6632.1999.tb07645.x
发表时间：
1999-01-01
期刊：
NEUROENDOCRINE IMMUNE BASIS OF THE RHEUMATIC DISEASES
影响因子：
--
作者：
Cutolo, M;Villaggio, B;Accardo, S
通讯作者：
Accardo, S