T cell responses in patients with COVID-19
T cell responses in patients with COVID-19
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DOI：
10.1038/s41577-020-0402-6
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发表时间：
2020-07-29
影响因子：
100.3
通讯作者：
John Wherry, E.
中科院分区：
文献类型：
--
作者：
Chen, Zeyu;John Wherry, E.
T细胞在COVID-19缓解或加重中的作用，以及它们提供长期保护免受SARS-CoV-2再感染的潜力，仍然存在争议。尽管如此，最近的研究已经强调了T细胞对SARS-CoV-2感染的反应的各个方面，这些研究开始使一些一般概念出现。John Wherry总结了在COVID-19患者中观察到的T细胞反应的早期报告，强调了不同患者的不同免疫反应特征如何反映疾病表型谱。
The role of T cells in the resolution or exacerbation of COVID-19, as well as their potential to provide long-term protection from reinfection with SARS-CoV-2, remains debated. Nevertheless, recent studies have highlighted various aspects of T cell responses to SARS-CoV-2 infection that are starting to enable some general concepts to emerge.In this Progress article, Zeyu Chen and E. John Wherry summarize early reports of the T cell responses observed in patients with COVID-19, emphasizing how different immune response characteristics in different patients may reflect a spectrum of disease phenotypes.