A simple and straightforward synthesis of phenyl isothiocyanates, symmetrical and unsymmetrical thioureas under ball milling
A simple and straightforward synthesis of phenyl isothiocyanates, symmetrical and unsymmetrical thioureas under ball milling
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球磨下简单直接地合成异硫氰酸苯酯、对称和不对称硫脲
DOI：
10.1039/c3ra43252a
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发表时间：
2013-01-01
期刊：
影响因子：
3.9
通讯作者：
Tan, Ya-Jun
中科院分区：
文献类型：
--
作者：
Zhang, Ze;Wu, Hao-Hao;Tan, Ya-Jun
由KOH在球铣削下促进的苯胺有效地转化为异硫氰酸酯（在5.0eberiv。CS2的存在下）或对称的thioureas（在1.0eberiv。cs2的情况下），而无需使用任何其他刺激性或有毒的分解试剂。一些原位产生的异硫氰酸盐可以直接“与其他胺”单击''，以负担不对称的thioureas。
Promoted by KOH under ball milling, anilines were efficiently transformed into isothiocyanates (in presence of 5.0 equiv. CS2) or symmetrical thioureas (in presence of 1.0 equiv. CS2), without using any other harsh or toxic decomposition reagent. Some in situ generated isothiocyanates can directly "click'' with other amines to afford unsymmetrical thioureas.