HEPATIC MR-IMAGING WITH FERUMOXIDES - A MULTICENTER CLINICAL-TRIAL OF THE SAFETY AND EFFICACY IN THE DETECTION OF FOCAL HEPATIC-LESIONS
HEPATIC MR-IMAGING WITH FERUMOXIDES - A MULTICENTER CLINICAL-TRIAL OF THE SAFETY AND EFFICACY IN THE DETECTION OF FOCAL HEPATIC-LESIONS
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DOI：
10.1148/radiology.196.2.7617864
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发表时间：
1995-08-01
期刊：
影响因子：
19.7
通讯作者：
JACOBS, PM
中科院分区：
文献类型：
--
作者：
ROS, PR;FREENY, PC;JACOBS, PM
目的：评价静脉注射超顺磁性氧化铁在磁共振(MR)上显示肝局灶性病变的安全性和诊断效果。材料和方法：这项开放研究包括208例已知或可疑肝局灶性病变的患者。分别于静脉注射阿魏酸钠(10 mU·m o l/kg)前、45分钟至4小时后进行磁共振成像。定量分析阿魏酸钠对肝脏信号强度的影响。安全性通过患者监护和实验室测量进行评估。结果：平扫和增强后T2加权图像的平均病灶与肝脏的对比噪声比分别为9.1和12.7。正常肝脏增强后信号强度降至平扫的37%。在图像盲法评估中，27%的增强图像上发现了额外的病变。结论：阿魏酸钠是一种安全有效的T2加权像肝脏局灶性病变的对比剂。
PURPOSE: To assess the safety and diagnostic efficacy of intravenous ferumoxides, a superparamagnetic iron oxide, for depiction of focal hepatic lesions on magnetic resonance (MR) images.MATERIALS AND METHODS: This open-label study included 208 patients with known or suspected focal hepatic lesions. MR images were obtained before and 45 minutes to 4 hours after intravenous infusion of ferumoxides (10 mu mol/kg). The effect of ferumoxides on signal intensity of the liver was assessed with quantitative analysis. Safety was evaluated with patient monitoring and laboratory measurements.RESULTS: Mean lesion-to-liver contrast-to-noise ratio on T2-weighted images was 9.1 on unenhanced images and 12.7 on enhanced images. Signal intensity of normal liver on enhanced images decreased to 37% of that on unenhanced images. In blinded image evaluations, additional lesions were identified on 27% of enhanced images. No serious adverse events occurred.CONCLUSION: Ferumoxides is a safe and efficacious contrast agent for the detection of focal liver lesions on T2-weighted images.