COMPARATIVE-STUDY ON HEMORRHAGIC AND PROTEOLYTIC ACTIVITIES OF SNAKE-VENOMS
COMPARATIVE-STUDY ON HEMORRHAGIC AND PROTEOLYTIC ACTIVITIES OF SNAKE-VENOMS
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DOI：
10.1016/0041-0101(80)90049-5
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发表时间：
1980-01-01
期刊：
影响因子：
2.8
通讯作者：
PEREZ, JC
中科院分区：
文献类型：
--
作者：
HUANG, SY;PEREZ, JC
测量了 9 种蛇毒 [Crotalus atrox、C. durissus、C. horridus、Agkistrodon rhodostoma、A. bilineatus、Vipera palaestinae、V. russelli、Pseudocerastes fieldi、Trimeresurus flavoviridis] 的出血滴度和蛋白水解滴度。选择合适的毒液稀释度来研究 3 种动物血清的抗出血和抗蛋白水解活性，即灰林鼠 (Neotoma micropus)、刚毛棉鼠 (Sigmodon hispidus) 和弗吉尼亚负鼠 (Didelphis virginiana)。所有出血性毒液均具有蛋白水解性。毒液的出血活性很容易被血清中和。蛋白水解活性未被中和。中和这两种活动所涉及的机制并不密切相关。
Hemorrhagic and proteolytic titers of 9 snake venoms [Crotalus atrox, C. durissus, C. horridus, Agkistrodon rhodostoma, A. bilineatus, Vipera palaestinae, V. russelli, Pseudocerastes fieldi, Trimeresurus flavoviridis] were measured. Suitable venom dilutions were selected to study antihemorrhagic and antiproteolytic activities of 3 animal sera, i.e., gray woodrat (Neotoma micropus), hispidus cottonrat (Sigmodon hispidus) and Virginia opossum (Didelphis virginiana). All hemorrhagic venoms were proteolytic. Hemorrhagic activity of venoms was readily neutralized by sera. Proteolytic activity was not neutralized. Mechanisms involved in neutralizing the 2 activities were not closely related.