Association between circadian rhythms, sleep and cognitive impairment in healthy older adults: an actigraphic study
Association between circadian rhythms, sleep and cognitive impairment in healthy older adults: an actigraphic study
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健康老年人的昼夜节律、睡眠和认知障碍之间的关联：一项活动记录研究
DOI：
10.1007/s00702-012-0802-2
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发表时间：
2012-10-01
影响因子：
3.3
通讯作者：
Coogan, Andrew N.
中科院分区：
文献类型：
--
作者：
Cochrane, Andy;Robertson, Ian H.;Coogan, Andrew N.
越来越多的证据表明，昼夜节律紊乱与老年人认知能力下降之间存在联系。本研究测量了一小组健康的社区居住老年人（n = 26）的昼夜活动节律。每个参与者都完成了一系列神经心理学测试，并完成了睡眠日记和6天的活动记录。10名参与者被确定为具有认知能力下降的早期迹象，这一点通过他们在记忆测试中的表现来表明。结果显示，两组之间的睡眠/活动和昼夜节律参数差异很小（下降与完整），尽管下降组和完整组之间的顶相存在显著差异。这些研究结果，虽然探索性的，表明非常微妙的变化，昼夜节律可能会检测到老年人显示临床前的认知能力的变化。
There is increasing evidence for the relationship between circadian rhythm disturbance and cognitive decline in the older adult. This study measured circadian activity rhythms in a small group of healthy community-dwelling older adults (n = 26). Each participant completed a battery of neuropsychological tests and completed sleep diaries and 6 days of actigraphy. Ten participants were identified as having very early signs of cognitive decline as indicated by their performance on the memory tests. Results showed minimal differences on the sleep/activity and circadian parameters across the two groups (declined vs. intact), although there was a significant difference in the acrophase between the declined and intact groups. These findings, although exploratory, suggest that very subtle changes in circadian rhythm may be detected in older adults showing pre-clinical changes in cognitive performance.