Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy.
Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy.
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DOI：
10.1016/j.neuroscience.2014.09.061
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发表时间：
2015-08-27
期刊：
影响因子：
3.3
通讯作者：
Wilcock DM
中科院分区：
文献类型：
--
作者：
Latta CH;Brothers HM;Wilcock DM
神经炎症长期以来一直被认为是阿尔茨海默病的伴随病理。在Alois Alzheimer的原始出版物中描述了Auguste D大脑中淀粉样蛋白斑块周围的小胶质细胞。然而，直到最近，我们才对神经炎症在神经退行性疾病（如阿尔茨海默氏症）中的不同作用有了更全面的认识。虽然我们的知识仍然存在差距，并且该领域存在大量相互矛盾的数据，但我们对阿尔茨海默氏症炎症反应的复杂性和异质性功能的理解得到了极大的改善。这篇综述文章将讨论神经炎症在阿尔茨海默病中的一些作用，特别是如何理解个体炎症反应的异质性可以用于治疗开发和作为个性化治疗疾病的机制。
Neuroinflammation has long been known as an accompanying pathology of Alzheimer’s disease. Microglia surrounding amyloid plaques in the brain of Auguste D were described in the original publication of Alois Alzheimer. It is only quite recently, however, that we have a more complete appreciation for the diverse roles of neuroinflammation in neurodegenerative disorders such as Alzheimer’s. While gaps in our knowledge remain, and conflicting data is abound in the field, our understanding of the complexities and heterogeneous functions of the inflammatory response in Alzheimer’s is vastly improved. This review article will discuss some of the roles of neuroinflammation in Alzheimer’s disease, in particular, how understanding heterogeneity in the individual inflammatory response can be used in therapeutic development and as a mechanism of personalizing our treatment of the disease.