36− and 48‐Month Neurobehavioral Follow‐up of Children Prenatally Exposed to Marijuana, Cigarettes, and Alcohol
36− and 48‐Month Neurobehavioral Follow‐up of Children Prenatally Exposed to Marijuana, Cigarettes, and Alcohol
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对产前接触大麻、香烟和酒精的儿童进行 36 个月和 48 个月的神经行为随访
DOI：
10.1097/00004703-199004000-00003
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发表时间：
1990
影响因子：
2.4
通讯作者：
B. Watkinson
中科院分区：
文献类型：
--
作者：
P. Fried;B. Watkinson
在133个36个月和130个48个月大的儿童，产前暴露于大麻，香烟和酒精的神经行为发育方面进行了检查，以前已经确定，并已自出生以来进行了评估。与12个月和24个月时对该样本的早期观察结果一致，在对混杂因素进行统计学控制后，产前吸烟与36个月和48个月时语言发育较差和认知评分较低显著相关。母亲饮酒水平相对较低，在24个月和36个月时有可测量的影响，在48个月时与结果变量不再有显着关系。在48个月时，在调整混杂变量后，语言和记忆领域的得分显着降低与母亲使用大麻有关。这种负相关性是首次报告的新生儿阶段以外的相关性，可能代表药物对复杂行为的长期影响，这些行为在较年轻时尚未发展和/或无法评估。
Aspects of neurobehavioral development were examined in 133 36-month- and 130 48-month-old children for whom prenatal exposure to marijuana, cigarettes, and alcohol had been previously ascertained and who have been assessed since birth. Parallelling earlier observations made with this sample at 12 and 24 months, prenatal exposure to cigarette smoking was significantly associated with poorer language development and lower cognitive scores at both 36 and 48 months after statistically controlling for confounding factors. Relatively low levels of maternal alcohol consumption, which had measurable effects at 24 and 36 months, no longer had significant relationships with outcome variables at 48 months of age. At 48 months, significantly lower scores in verbal and memory domains were associated with maternal marijuana use after adjusting for confounding variables. This negative relationship is the first reported association beyond the neonatal stage, and may represent a long-term effect of the drug upon complex behavior that, at a younger age, had not developed and/or could not be assessed.