Finding biomarkers for non-small cell lung cancer diagnosis and prognosis
Finding biomarkers for non-small cell lung cancer diagnosis and prognosis
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寻找非小细胞肺癌诊断和预后的生物标志物
DOI：
10.1007/s11515-011-1163-1
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Ji H
中科院分区：
文献类型：
--
作者：
Xiao T;Bao L;Ji H
尽管经过几十年的努力，肺癌仍然是最致命的疾病之一，全世界的 5 年生存率约为 15%。在中国，情况更糟。虽然目前还没有官方数据公布，但预计5年生存率在10%左右。过去30年，中国大陆肺癌相关死亡急剧增加约465%。每年约有40万人死于肺癌，而且这个数字还在不断攀升。与此同时，肺癌新发病例数也迅速增加。肺癌的高死亡率主要归因于两个因素：缺乏有效的方法来识别早期诊断生物标志物和治疗转移性癌症。肺癌从病理上可分为小细胞肺癌（SCLC）和非小细胞肺癌（NSCLC），其中NSCLC约占全部病例的80%。在这篇综述中，我们将重点关注最近在寻找非小细胞肺癌生物标志物方面的努力和进展。由于生物标志物来源于侵入性和非侵入性方式，因此我们将它们分为这两类并分别进行审查。我们希望生物标志物的发现最终能够改变NSCLC患者当前的临床实践并提高他们的生活质量。
Despite of several decades of efforts, lung cancer remains one of most deadly diseases, with a 5-year survival rate approximately 15% worldwide. In China, the situation is even worse. Although there is no official data released yet, the 5-year survival rate is estimated to be around 10%. In past 30 years, there was a dramatic increase of lung cancer related death about 465% in mainland China. Annually, about 400000 people die of lung cancer and the number is still climbing. At the same time, the number of new lung cancer cases also increase rapidly. The high mortality of lung cancer is mainly ascribed to two factors: the lack of effective ways to identify early diagnostic biomarkers and to treat metastatic cancer. Lung cancer can be pathologically divided into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC), among which NSCLC accounts for about 80% of all cases. In this review, we will focus on the recent efforts and progress in finding biomarkers in NSCLC. Since biomarkers are derived from both invasive and noninvasive ways, we divide them into these two categories and review them separately. We hope the discovery of biomarkers will eventually change the current clinical practice in NSCLC patients and improve their quality of life.
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DOI：
10.1016/b978-0-12-812832-9.00003-8
发表时间：
2019
期刊：
Genes, Brain Function, and Behavior
影响因子：
--
作者：
D. Wahlsten
通讯作者：
D. Wahlsten
影响因子：
3.3
作者：
Rodriguez-Pineiro, A. M.;Blanco-Prieto, S.;Paez de la Cadena, M.
通讯作者：
Paez de la Cadena, M.
影响因子：
30.8
作者：
McKay, James D.;Hung, Rayjean J.;Gaborieau, Valerie;Boffetta, Paolo;Chabrier, Amelie;Byrnes, Graham;Zaridze, David;Mukeria, Anush;Szeszenia-Dabrowska, Neonilia;Lissowska, Jolanta;Rudnai, Peter;Fabianova, Eleonora;Mates, Dana;Bencko, Vladimir;Foretova, Lenka;Janout, Vladimir;McLaughlin, John;Shepherd, Frances;Montpetit, Alexandre;Narod, Steven;Krokan, Hans E.;Skorpen, Frank;Elvestad, Maiken Bratt;Vatten, Lars;Njolstad, Inger;Axelsson, Tomas;Chen, Chu;Goodman, Gary;Barnett, Matt;Loomis, Melissa M.;Lubinski, Jan;Matyjasik, Joanna;Lener, Marcin;Oszutowska, Dorota;Field, John;Liloglou, Triantafillos;Xinarianos, George;Cassidy, Adrian;Zelenika, Diana;Boland, Anne;Delepine, Marc;Foglio, Mario;Lechner, Doris;Matsuda, Fumihiko;Blanche, Helene;Gut, Ivo;Heath, Simon;Lathrop, Mark;Brennan, Paul
通讯作者：
Brennan, Paul
DOI：
10.1016/s0090-3671(08)70289-1
发表时间：
2007
期刊：
Yearbook of Surgery
影响因子：
--
作者：
David E Jones
通讯作者：
David E Jones
使用糖蛋白捕获和液相色谱质谱法发现肺癌血清生物标志物。
影响因子：
4.4
作者：
Zeng, Xuemei;Hood, Brian L.;Sun, Mai;Conrads, Thomas P.;Day, Roger S.;Weissfeld, Joel L.;Siegfried, Jill M.;Bigbee, William L.
通讯作者：
Bigbee, William L.