Hypothermia: a systematic review and meta-analysis of clinical trials
Hypothermia: a systematic review and meta-analysis of clinical trials
复制标题
DOI：
10.1016/j.siny.2010.02.003
复制
发表时间：
2010-10-01
影响因子：
3
通讯作者：
Shah, Prakesh S.
中科院分区：
文献类型：
--
作者：
Shah, Prakesh S.
低温是治疗新生儿窒息后缺氧缺血性脑病（HIE）的一种潜在的神经保护干预措施。在迄今为止发表的13项临床试验的荟萃分析中，治疗性低温与儿童期死亡或中度至重度神经发育障碍的综合结局风险的高度可重复性降低相关。这种改善是内在一致的，如死亡、中度至重度神经发育障碍、重度脑瘫、认知延迟和精神发育延迟的个体风险显著降低所示。低温组患者心律失常和血小板减少症的发生率较高;然而，这些在临床上并不重要。该分析支持使用低温降低中度HIE婴儿的死亡率或中度至重度神经发育障碍的风险。(c)2010爱思唯尔有限公司保留所有权利。
Hypothermia is a potential neuroprotective intervention to treat neonatal post-asphyxial (hypoxic ischemic) encephalopathy (HIE). In this meta-analysis of 13 clinical trials published to date, therapeutic hypothermia was associated with a highly reproducible reduction in the risk of the combined outcome of mortality or moderate-to-severe neurodevelopmental disability in childhood. This improvement was internally consistent, as shown by significant reductions in the individual risk for death, moderate-to-severe neurodevelopmental disability, severe cerebral palsy, cognitive delay, and psychomotor delay. Patients in the hypothermia group had higher incidences of arrhythmia and thrombocytopenia; however, these were not clinically important. This analysis supports the use of hypothermia in reducing the risk of the mortality or moderate-to-severe neurodevelopmental disability in infants with moderate HIE. (c) 2010 Elsevier Ltd. All rights reserved.