LEPTOMYCIN-A AND LEPTOMYCIN-B NEW ANTI-FUNGAL ANTIBIOTICS .1. TAXONOMY OF THE PRODUCING STRAIN AND THEIR FERMENTATION, PURIFICATION AND CHARACTERIZATION
LEPTOMYCIN-A AND LEPTOMYCIN-B NEW ANTI-FUNGAL ANTIBIOTICS .1. TAXONOMY OF THE PRODUCING STRAIN AND THEIR FERMENTATION, PURIFICATION AND CHARACTERIZATION
复制标题
DOI：
10.7164/antibiotics.36.639
复制
发表时间：
1983-01-01
影响因子：
3.3
通讯作者：
BEPPU, T
中科院分区：
文献类型：
--
作者：
HAMAMOTO, T;GUNJI, S;BEPPU, T
一株链霉菌产生了新的抗真菌抗生素。采用高效液相色谱法对活性成分进行分离纯化，得到两种物质，分别命名为来普霉素A和B。柔红霉素A和B的分子式分别为C32 H46 O 6;它们的物理化学和生物学性质非常相似。瘦霉素A和B对裂殖酵母和毛霉有较强的抑制活性。
A strain of Streptomyces produced new antifungal antibiotics. The active compounds were purified and separated into 2 substances named leptomycin A and B by high performance liquid chromatography. The molecular formulae of leptomycins A and B are C32H46O6, respectively; their physicochemical and biological properties are very similar. Leptomycins A and B exhibited strong inhibitory activity against Schizosaccharomyces and Mucor.