American College of Surgeons Oncology Group Z4099/Radiation Therapy Oncology Group 1021: a randomized study of sublobar resection compared with stereotactic body radiotherapy for high-risk stage I non-small cell lung cancer.
American College of Surgeons Oncology Group Z4099/Radiation Therapy Oncology Group 1021: a randomized study of sublobar resection compared with stereotactic body radiotherapy for high-risk stage I non-small cell lung cancer.
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DOI：
10.1016/j.jtcvs.2012.06.003
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发表时间：
2012-09
期刊：
影响因子：
--
通讯作者：
Timmerman R
中科院分区：
文献类型：
--
作者：
Fernando HC;Timmerman R
在过去的十年中，非小细胞肺癌患者的非手术治疗引起了极大的兴趣。在这些疗法中，立体定向体部放射疗法已被确立为治疗医学上不能手术的患者的外周癌的有效方式。毒性低，治疗有效，局部控制率高。一些研究者认为，立体定向体部放射治疗对高风险可手术患者（通常采用肺叶切除术治疗）有效，甚至可能对标准风险可手术患者（通常采用肺叶切除术治疗）有效;然而，这一观点不太被接受。直接比较立体定向体部放疗和肺叶切除术是困难的，原因有很多。其中包括不同的复发定义，这些研究中不同的患者人群（接受立体定向体部放疗的患者倾向于成为医学上不可手术的组），以及手术和放射肿瘤学研究中不同的发病率分类方法。影像学随访在研究中也没有标准化。因此，随机研究是必要的和及时的。来自美国外科医师学会肿瘤学小组和放射治疗和肿瘤学小组的研究人员合作开发了一项III期随机研究，比较了立体定向体部放疗和肺叶切除术（有或没有近距离放射治疗）对高风险可手术的非小细胞肺癌患者的影响。本研究（美国外科医师学会肿瘤组Z4099/放射治疗肿瘤组1021）最近已开始招募。希望这将有助于更好地确定这些疗法对非小细胞肺癌患者的作用。
During the past decade, tremendous interest has arisen in the use of nonoperative therapies for patients with non–small cell lung cancer. Of these therapies, stereotactic body radiotherapy has become established as an effective modality for treating peripheral cancer in medically inoperable patients. Toxicity is low, and the treatment is effective, with excellent local control rates. Several investigators have suggested that stereotactic body radiotherapy could be effective for high-risk operable patients (usually treated with sublobar resection) and even perhaps for standard-risk operable patients (usually treated with lobectomy); however, this is less accepted. A direct comparison of stereotactic body radiotherapy and sublobar resection is difficult for a number of reasons. These include different definitions of recurrence, different populations of patients in these studies (with those undergoing stereotactic body radiotherapy tending to be the medically inoperable group), and different methods of classifying morbidity in the surgical and radiation oncology studies. Imaging follow-up has also not been standardized among the studies. Thus, a randomized study is necessary and timely. Investigators from the American College of Surgeons Oncology Group and the Radiation Therapy and Oncology Group have collaborated to develop a phase III randomized study comparing stereotactic body radiotherapy and sub-lobar resection (with or without brachytherapy) for high-risk operable patients with non–small cell lung cancer. This study (American College of Surgeons Oncology Group Z4099/Radiation Therapy Oncology Group 1021) has recently opened for accrual. It is hoped that this will help to better define the role of these therapies for patients with non–small cell lung cancer.
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影响因子：
9.6
作者：
Timmerman, R;Papiez, L;Williams, M
通讯作者：
Williams, M
DOI：
10.1016/j.jtcvs.2004.09.025
发表时间：
2005-02-01
影响因子：
6
作者：
Fernando, HC;Santos, RS;Landreneau, RJ
通讯作者：
Landreneau, RJ
影响因子：
2.1
作者：
Pettiford, Brian L;Schuchert, Matthew J;Landreneau, Rodney J
通讯作者：
Landreneau, Rodney J
影响因子：
5.7
作者：
Wulf, J;Hädinger, U;Flentje, M
通讯作者：
Flentje, M
影响因子：
20.4
作者：
Onishi, Hiroshi;Shirato, Hiroki;Araki, Tsutomu
通讯作者：
Araki, Tsutomu