Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder
Evidence that variation in the peripheral benzodiazepine receptor (PBR) gene influences susceptibility to panic disorder
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DOI：
10.1002/ajmg.b.30211
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发表时间：
2006-04-05
影响因子：
2.8
通讯作者：
Mori, N
中科院分区：
文献类型：
--
作者：
Nakamura, K;Yamada, K;Mori, N
惊恐障碍（PD）是反复突然发生的惊恐发作，以心理症状为特征的发作。外周苯二氮卓受体（PBR）与焦虑耐受性的人格特征密切相关，并且它有望成为压力状况的生物标志物。我们使用多态性进行关联分析以确定 PD 中的 PBR。我们筛选了受试者 5' 区域、编码区域（外显子 2-4）和 3' 非编码区域内的序列变异。在这些受试者中检测到外显子 4 中的一种新错义变异，源自密码子 162 中的核苷酸转换 (CGT -> CAT:485G > A)，导致精氨酸到组氨酸 (Arg -> His) 的变化。对 91 名 PD 患者和 178 名对照者的 PBR 基因 485G > 多态性进行了分析。 485G > A 的基因型和等位基因分析显示恐慌患者与对照组之间存在显着差异（P 分别为 0.021 和 0.014）。本研究提供了新的重要证据，证明 PBR 基因的变异影响 PD 的易感性。 (c) 2006 年 Wiley-Liss, Inc.
Panic disorder (PD) is the repeated sudden occurrence of panic attacks, episodes characterized by psychological symptoms. Peripheral benzodiazepine receptor (PBR) is closely associated with personality traits for anxiety tolerance, and that it holds promise as a biological marker of stressful conditions. We have performed association analyses using the polymorphism to determine the PBR in PD. We screened the subjects for sequence variations within the 5' region, the coding region (exons 2-4), and the 3' noncoding region. One novel missense variant in exon 4, derived from the nucleotide transition in codon 162 (CGT -> CAT:485G > A) resulting in an arginine-to-histidine (Arg -> His) change, was detected in these subjects. The 485G > polymorphism of the PBR gene was analyzed in 91 PD patients and 178 controls. The genotypic and allelic analyses of the 485G > A revealed significant differences between the panic patients and the comparison subjects (P=0.021 and 0.014, respectively). The present study provides new and important evidence that variation in the PBR gene influences susceptibility to PD. (c) 2006 Wiley-Liss, Inc.