Antibacterial Synergy of Glycerol Monolaurate and Aminoglycosides in Staphylococcus aureus Biofilms
Antibacterial Synergy of Glycerol Monolaurate and Aminoglycosides in Staphylococcus aureus Biofilms
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DOI：
10.1128/aac.03672-14
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发表时间：
2014-11-01
影响因子：
4.9
通讯作者：
Wells, Carol L.
中科院分区：
文献类型：
--
作者：
Hess, Donavon J.;Henry-Stanley, Michelle J.;Wells, Carol L.
甘油单月桂酸酯（GML）是一种具有抗菌性能的天然表面活性剂。在类似于0.3 mM的浓度下，GML及其组分月桂酸对耐药性金黄色葡萄球菌生物膜都具有杀菌作用。通过使用从嗜酸性细胞获得的抗生素的MIC，GML和月桂酸与庆大霉素和链霉素协同作用，但不与氨苄青霉素或万古霉素协同作用，以消除可检测到的活生物膜细菌。GML处理的生物膜的图像表明，GML可以促进抗生素与基质包埋的细菌的相互作用。
Glycerol monolaurate (GML) is a natural surfactant with antimicrobial properties. At similar to 0.3 mM, both GML and its component lauric acid were bactericidal for antibiotic-resistant Staphylococcus aureus biofilms. With the use of MICs of antibiotics obtained from planktonic cells, GML and lauric acid acted synergistically with gentamicin and streptomycin, but not ampicillin or vancomycin, to eliminate detectable viable biofilm bacteria. Images of GML-treated biofilms suggested that GML may facilitate antibiotic interaction with matrix-embedded bacteria.