The Macular Carotenoids Lutein and Zeaxanthin Are Related to Increased Bone Density in Young Healthy Adults
The Macular Carotenoids Lutein and Zeaxanthin Are Related to Increased Bone Density in Young Healthy Adults
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DOI：
10.3390/foods6090078
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发表时间：
2017-09-01
期刊：
影响因子：
5.2
通讯作者：
Hammond, Billy R.
中科院分区：
文献类型：
--
作者：
Bovier, Emily R.;Hammond, Billy R.
叶黄素（L）和玉米黄质（Z）的状态可以通过测量它们在血清中和非侵入性地在视网膜组织中的浓度来定量。这导致了一种独特的能力，以评估其在许多组织中的作用，从心血管到中枢神经系统组织。最近使用动物模型的报告提出了另一个作用，即骨量的发育增加。为了验证这一点，我们评估了63名年轻健康成年人的L和Z状态。通过测量血清中的LZ（使用HPLC）和视网膜组织中的LZ（使用定制的异色闪烁光度法测量黄斑色素光密度，MPOD）来确定LZ状态。采用双能X线骨密度仪（DXA）测量骨密度。虽然血清LZ通常与骨量无关，但MPOD与股骨近端和腰椎的骨密度显著相关。总的来说，我们的研究结果与类胡萝卜素，特别是LZ，在最佳骨骼健康中发挥作用是一致的。
Lutein (L) and zeaxanthin (Z) status can be quantified by measuring their concentrations both in serum and, non-invasively, in retinal tissue. This has resulted in a unique ability to assess their role in a number of tissues ranging from cardiovascular to central nervous system tissue. Recent reports using animal models have suggested yet another role, a developmental increase in bone mass. To test this, we assessed L and Z status in 63 young healthy adults. LZ status was determined by measuring LZ in serum (using HPLC) and retina tissue (measuring macular pigment optical density, MPOD, using customized heterochromatic flicker photometry). Bone density was measured using dual-energy X-ray absorptiometry (DXA). Although serum LZ was generally not related to bone mass, MPOD was significantly related to bone density in the proximal femur and lumbar spine. In general, our results are consistent with carotenoids, specifically LZ, playing a role in optimal bone health.