White blood cell count is associated with macro- and microvascular complications in Chinese patients with type 2 diabetes
White blood cell count is associated with macro- and microvascular complications in Chinese patients with type 2 diabetes
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DOI：
10.2337/diacare.27.1.216
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发表时间：
2004-01-01
期刊：
影响因子：
16.2
通讯作者：
Chan, JC
中科院分区：
文献类型：
--
作者：
Tong, PC;Lee, KF;Chan, JC
在一般人群中，白色血细胞（WBC）计数升高、冠心病和代谢综合征之间存在密切联系。白细胞计数和糖尿病血管并发症之间的关系尚未探讨。我们进行了一项横断面队列研究，以确定白细胞计数与2型糖尿病大血管和微血管并发症之间的关系。776例WBC计数正常的2型糖尿病患者（3.5-12.5 X 10（9）/l）进行了基于欧洲DiabCare方案的并发症和心血管风险因素的全面评估。记录人口统计学和人体测量学参数。结果：白细胞计数较高的患者（分为五分位数）有不良的代谢特征，表现为血压、BMI、HbA（1c）、空腹血糖、LDL胆固醇、甘油三酯和尿白蛋白排泄量较高，但HDL胆固醇较低（均P < 0.05）。
OBJECTIVES - There are close associations among raised white blood cell (WBC) count, coronary heart disease, and metabolic syndrome in the general population. The association between WBC count and vascular complications of diabetes has not been explored. We carried out a cross-sectional cohort study to determine the association between WBC count and the presence of macro- and microvascular complications in type 2 diabetes.RESEARCH DESIGN AND METHODS in this study, 3,776 patients with type 2 diabetes and normal WBC count (3.5-12.5 X 10(9)/l) underwent a comprehensive assessment of complications and cardiovascular risk factors based on the European DiabCare protocol. Demographic and anthropometric parameters were recorded. Metabolic profiles, including complete blood picture and urinary albumin excretion, were measured.RESULTS - Patients with higher WBC counts (categorized into quintiles) had adverse metabolic profiles as evidenced by higher blood pressure, BMI, HbA(1c), fasting plasma glucose, LDL cholesterol, triglycerides, and urinary albumin excretion, but lower HDL cholesterol (all P