The Correlation between MicroRNA-199a and White Adipose Tissue in C57/BL6J Mice with High-Fat Diet
The Correlation between MicroRNA-199a and White Adipose Tissue in C57/BL6J Mice with High-Fat Diet
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MicroRNA-199a与高脂饮食C57/BL6J小鼠白色脂肪组织的相关性
DOI：
10.36959/433/562
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发表时间：
2018-03
影响因子：
2.3
通讯作者：
Wang Xia
中科院分区：
文献类型：
--
作者：
Liu Dan;Lijuan Du;Xinying Lin;Wenwen Guo;Baihui Zhang;Wang Xia
人们逐渐认识到 microRNA 作为白色脂肪组织 (WAT) 和肥胖调节的介质。研究小鼠中 miR-199a 的表达水平来检验我们的假设：miR-199a 可能与脂肪积累有关。我们试图找到它的目标 mRNA，这也许可以提出具有影响脂肪储存治疗潜力的策略。 C57/BL6J 小鼠被随机分配到对照组或肥胖模型组（两组均为 10 只）。
Understanding is emerging about microRNAs as mediators in the regulation of white adipose tissue (WAT) and obesity. The expression level of miR-199a in mice was investigated to test our hypothesis: miR-199a might be related to fat accumulation. And we try to find its target mRNA, which perhaps could propose strategies with a therapeutic potential affecting the fat storage. C57/BL6J mice were randomly assigned to either a control group or an obesity model group (n = 10 in both groups).