Maintenance of enriched environment-induced changes of auditory spatial sensitivity and expression of GABAA, NMDA, and AMPA receptor subunits in rat auditory cortex
Maintenance of enriched environment-induced changes of auditory spatial sensitivity and expression of GABAA, NMDA, and AMPA receptor subunits in rat auditory cortex
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DOI：
10.1016/j.nlm.2010.08.008
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发表时间：
2010-11-01
影响因子：
2.7
通讯作者：
Sun, Xinde
中科院分区：
文献类型：
--
作者：
Cai, Rui;Zhou, Xiaoming;Sun, Xinde
丰富环境对脑的发育和可塑性有重要作用。本研究探讨了丰富环境对早期脑空间敏感性的维持及其可能的机制。对照组：EE大鼠恢复正常状态2个月后，A1区神经元的空间敏感性仍增强。早期EE暴露大鼠的增强表现为更尖锐的频率调谐曲线、更小的空间感受野和更有选择性的方向曲线。同时，我们检测到GABA（A）受体α（1）β（3）亚基NMDA受体NR 2A NR 2B亚基AMPA受体GluR 2亚基蛋白表达以及GABA（A）alpha 1/GABA（A）alpha 3和NR 2A/NR 2B特别是在早期EE中GABA（A）α 1/GABA（A）α 3的表达比率变化显著大于NR 2A/NR 2B。这些结果表明，早期EE暴露诱导的持续高水平的GABA能和谷氨酸能受体表达，特别是增强了听皮层的GABA能抑制，可能是维持改善效应的原因。大鼠恢复正常状态后的听觉空间灵敏度（C）2010 Elsevier Inc版权所有
Enriched environment (EE) has an Important role in the development and plasticity of the brain In this study we investigated the maintenance of early EE exposure-Induced changes of spatial sensitivity and the possible underlying mechanisms of this maintenance We found that compared with the age-matched control the spatial sensitivity of A1 neurons was still enhanced after EE rats had been returned to the normal condition for 2 months The enhancement was expressed by a sharper frequency tuning curve smaller spatial receptive field and a more selective directional curve of the early EE-exposed rats Simultaneously we detected significant increases in GABA(A) receptor alpha(1) beta(3) subunits NMDA receptor NR2A NR2B subunits AMPA receptor GluR2 subunit protein expression and in the ratios of GABA(A)alpha 1/GABA(A)alpha 3 and NR2A/NR2B In particular the expression ratio change of the GABA(A)alpha 1/GABA(A)alpha 3 was significant greater than that of NR2A/NR2B in early EE-exposed rats These observations indicate that the persistent higher expression levels of the GABAergic and glutamatergic receptors expression induced by early EE exposure especially enhancement of GABAergic inhibition in the auditory cortex might be responsible for the maintenance of Improved effects in auditory spatial sensitivity after the rats had been returned to the normal condition (C) 2010 Elsevier Inc All rights reserved