Analysis of association between IL-1β, CASP-9, and GDF5 variants and low-back pain in Chinese male soldiers Clinical article
Analysis of association between IL-1β, CASP-9, and GDF5 variants and low-back pain in Chinese male soldiers Clinical article
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DOI：
10.3171/2013.4.spine12782
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发表时间：
2013-08-01
影响因子：
2.8
通讯作者：
Huang, Changlin
中科院分区：
文献类型：
--
作者：
Mu, Jihong;Ge, Weiming;Huang, Changlin
物体。最近的研究表明，遗传危险因素在腰痛(LBP)和腰椎间盘疾病的发生中起着重要作用。作者的研究旨在评估3个单核苷酸多态(SNPs)与军事训练相关的LBP易感性的关系。在这项病例对照研究中，对892名中国男性士兵的资料进行了回顾。病例组由305名与军事训练相关的下腰痛士兵组成，另587名士兵为对照组，无持续下腰痛2周以上。从受试者外周血白细胞中提取基因组DNA，聚合酶链式反应产物进行基因分型。未发现IL-1β单核苷酸多态(IL-1β；+3954C/T)与LBP在基因水平(p=0.104)和等位基因水平(p=0.098)之间存在关联。但Caspase-9的G等位基因(CASP-9)和生长分化因子5的T等位基因(GDF5)在腰背痛患者中的分布频率明显高于非腰痛患者(p<；0.001)。在中国军队队列中的研究结果表明，CASP-9(-1263A/G)和GDF5(+104T/C)基因多态性与军事训练相关的LBP易感性相关。
Object. Recent studies have suggested that genetic risk factors play an important role in the occurrence of low-back pain (LBP) and lumbar disc disease. The authors' study aimed to assess the association between 3 single-nucleotide polymorphisms (SNPs) and susceptibility to LBP related to military training.Methods. In this case-control study, data from 892 Chinese male soldiers were retrospectively reviewed. The case group was made up of 305 soldiers with LBP related to military training and a control group of 587 soldiers without constant LBP for more than 2 weeks. Genomic DNA was extracted from peripheral blood leukocytes of all subjects and polymerase chain reaction products were genotyped.Results. No association was found between the SNP of interleukin-1 beta (IL-1 beta; +3954C/T) and LBP at both the genotypic (p = 0.104) and the allelic (p = 0.098) level. However, the G allele of caspase-9 (CASP-9) and the T allele of growth differentiation factor 5 (GDF5) were more common in patients with LBP than in patients without LBP (p < 0.001).Conclusions. The findings in a Chinese military cohort indicated that CASP-9 (-1263A/G) and GDF5 (+104T/C) polymorphisms are associated with a susceptibility to LBP related to military training.