Recurrent empty follicle syndrome successfully treated with recombinant human chorionic gonadotrophin.
Recurrent empty follicle syndrome successfully treated with recombinant human chorionic gonadotrophin.
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DOI：
10.1093/humrep/14.7.1703
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发表时间：
1999-07
影响因子：
6.1
通讯作者：
J. Peñarrubia;Juan Balasch;F. Fábregues;M. Creus;S. Cívico;J. Vanrell
中科院分区：
文献类型：
--
作者：
J. Peñarrubia;Juan Balasch;F. Fábregues;M. Creus;S. Cívico;J. Vanrell
我们报告一例多囊卵巢综合征并原发不育症患者，因其配偶严重少精子症和弱精子症而接受体外受精(IVF)/卵母细胞浆内单精子注射(ICSI)。在口服避孕药抑制卵巢和促性腺激素释放激素激动剂治疗的双重方法之后，在三个治疗周期中使用促性腺激素治疗完成卵巢刺激。尽管使用了三个不同批次的人绒毛膜促性腺激素(HCG)，但在前两个处理周期中，获取卵母细胞失败。第三个周期采用重组人绒毛膜促性腺激素，共采集5个卵母细胞。这是尽管使用了不同批次的商业尿液HCG，但复发的空卵泡综合征的第一个报告，并成功地使用重组HCG治疗。
We report a case of a patient with polycystic ovary syndrome and primary infertility who was admitted to our in-vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) programme because of her partner's severe oligozoospermia and asthenozoospermia. Ovarian stimulation was accomplished in the three treatment cycles using gonadotrophin therapy after a dual approach with ovarian suppression using oral contraceptive pills followed by gonadotrophin-releasing hormone agonist therapy. Oocyte retrieval was unsuccessful in the first two treated cycles despite the fact that human chorionic gonadotrophin (HCG) from three different batches was used. In the third treatment cycle, recombinant HCG was used and five oocytes were retrieved. This is the first report of recurrent empty follicle syndrome despite the use of different batches of commercially available urinary HCG, and of its successful treatment using recombinant HCG.