Circulating TNF Receptor 2 is Closely Associated with the Kidney Function in Non-Diabetic Japanese Subjects
Circulating TNF Receptor 2 is Closely Associated with the Kidney Function in Non-Diabetic Japanese Subjects
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DOI：
10.5551/jat.21055
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发表时间：
2014-01-01
影响因子：
4.4
通讯作者：
Taniguchi, Ataru
中科院分区：
文献类型：
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作者：
Kurashina, Tomoyuki;Nagasaka, Shoichiro;Taniguchi, Ataru
目的：慢性肾脏病（CKD）与心血管事件相关。肿瘤坏死因子（TNF）和/或其受体已被假定参与肾脏病理生理学。目前尚不清楚在出现明显的CKD之前是否存在TNF系统活性增加。方法：招募420名估计GFR（eGFR）大于60 ml/min/1.73 m2的非糖尿病日本受试者，测量HbA 1c、胰岛素、TNF系统活性（TNF-α、可溶性TNF受体1（sTNF-R1）和sTNF-R2）水平和各种参数，包括脂质、高敏C反应蛋白（hsCRP）、高分子量（HMW）脂联素和瘦素水平。根据eGFR对受试者进行分层：G1水平（eGFR >= 90 ml/min/1.73 m（2））和G2水平（90 > eGFR >= 60 ml/min/1.73 m（2））。而两组在性别、体重指数（BMI）、血压、胰岛素、TNF-α、hsCRP、HMW脂联素和瘦素方面无显著差异，eGFR水平为G2的受试者的年龄、HbA 1c、甘油三酯、sTNF-R1和sTNF-R2值显著高于eGFR水平为G1的受试者。相反，HDL胆固醇水平在G2水平的受试者中显著低于G1水平的受试者。eGFR分别与年龄、BMI、HbA 1c、甘油三酯、sTNF-R1和sTNF-R2呈线性负相关。多元Logistic回归分析显示，在日本非糖尿病患者中，只有sTNF-R2与eGFR G2水平相关（比值比1.092，95%CI 1.013-1.177，P=0.021）。
Aim: Chronic kidney disease (CKD) is associated with cardiovascular events. Tumor necrosis factor (TNF) and/or its receptors have been postulated to be involved in renal pathophysiology. It is unclear whether an increased TNF system activity is present before the development of apparent CKD.Methods: Four hundred and twenty non-diabetic Japanese subjects with an estimated GFR (eGFR) greater than 60 ml/min/1.73 m(2) were recruited for measurement of the HbA1c, insulin, TNF system activity (TNF-alpha, soluble TNF receptor 1 (sTNF-R1) and sTNF-R2) levels and various parameters, including the lipid, high-sensitivity C-reactive protein (hsCRP), high-molecular-weight (HMW) adiponectin and leptin levels. The subjects were stratified according to the eGFR: the G1 level (eGFR >= 90 ml/min/1.73 m(2)) and the G2 level (90 > eGFR >= 60 ml/min/1.73 m(2)).Results: Whereas no significant differences were observed in gender, body mass index (BMI), blood pressure, insulin, TNF-alpha, hsCRP, HMW adiponectin or leptin between the two groups, the values for age, HbA1c, triglycerides, sTNF-R1 and sTNF-R2 were significantly higher in the subjects with a G2 level of eGFR than in those with a G1 level. In contrast, the HDL cholesterol levels were significantly lower in the subjects with a G2 level than in those with a G1 level. Linear negative correlations were also observed between eGFR and age, BMI, HbA1c, triglycerides, sTNF-R1 and sTNF-R2, respectively. A multiple logistic regression analysis revealed that only sTNF-R2 was associated with the presence of a G2 level of eGFR (Odds ratio 1.092, 95% CI 1.013-1.177, P=0.021).Conclusions: The circulating sTNF-R2 level is closely associated with the kidney function in nondiabetic Japanese subjects.