Common features of megakaryocytes and hematopoietic stem cells: what's the connection?
Common features of megakaryocytes and hematopoietic stem cells: what's the connection?
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DOI：
10.1002/jcb.22184
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发表时间：
2009-08-01
影响因子：
4
通讯作者：
Cantor, Alan B.
中科院分区：
文献类型：
--
作者：
Huang, Hui;Cantor, Alan B.
巨核细胞是罕见的多倍体骨髓细胞，其功能是产生血小板。自从1994年主要的巨核细胞细胞因子血小板生成素被纯化和克隆以来，在理解巨核细胞发育的生物学方面已经取得了相当大的进展。值得注意的是，这些进展揭示了巨核细胞与造血干细胞（HSC）共有的许多关键特征，例如共同的表面受体、谱系特异性转录因子和专门的信号通路。为什么这两种细胞类型之间存在如此密切的联系仍不清楚。在这篇展望文章中，我们总结了支持这些共享特征的数据，并推测了可能的目的论基础。我们特别关注涉及发育层次、内皮细胞和骨髓生态位相互作用的共同联系。本讨论重点介绍了新数据，这些数据显示了发育过程中 HSC 与专门的“造血”内皮细胞之间密切的本体关系，以及巨核细胞/血小板与内皮细胞之间的功能重叠。总体而言，这些发现可能与 HSC 离体培养技术的开发和/或通过体细胞重编程可能产生 HSC 相关。
Megakaryocytes are rare polyploid bone marrow cells whose function is to produce blood platelets. Since the purification and cloning of the major megakaryocyte cytokine, thrombopoietin, in 1994, considerable progress has been made in understanding the biology of megakaryocyte development. Remarkably, these advances have revealed a number of key features of megakaryocytes that are shared with hematopoietic stem cells (HSCs), such as common surface receptors, lineage-specific transcription factors, and specialized signaling pathways. Why there should be such a close connection between these two cell types remains unclear. In this Prospects article, we summarize the data supporting these shared features and speculate on possible teleological bases. In particular, we focus on common links involving developmental hierarchy, endothelial cells, and bone marrow niche interactions. This discussion highlights new data showing close ontologic relationship between HSCs and specialized “hemogenic” endothelial cells during development, and functional overlap between megakaryocytes/platelets and endothelial cells. Overall, these findings may be of relevance in the development of techniques for HSC ex vivo culture and/or possible generation of HSCs via somatic cell reprogramming.
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影响因子：
64.8
作者：
Chen, Michael J.;Yokomizo, Tomomasa;Zeigler, Brandon M.;Dzierzak, Elaine;Speck, Nancy A.
通讯作者：
Speck, Nancy A.
影响因子：
64.5
作者：
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通讯作者：
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DOI：
10.1073/pnas.95.3.1195
发表时间：
1998-02-03
影响因子：
11.1
作者：
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通讯作者：
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影响因子：
64.5
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Orkin, Stuart H.