CHARACTERIZATION OF SITES OF TYROSINE SULFATION IN PROTEINS AND CRITERIA FOR PREDICTING THEIR OCCURRENCE
CHARACTERIZATION OF SITES OF TYROSINE SULFATION IN PROTEINS AND CRITERIA FOR PREDICTING THEIR OCCURRENCE
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DOI：
10.1016/s0006-291x(86)80372-2
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发表时间：
1986-11-26
影响因子：
3.1
通讯作者：
STRAUSS, AW
中科院分区：
文献类型：
--
作者：
HORTIN, G;FOLZ, R;STRAUSS, AW
最近发现多种分泌蛋白经历特定酪氨酸残基的翻译后硫酸化。在这里，分析蛋白质中已知硫酸化位点周围的氨基酸序列，以确定决定硫酸化特异性的因素。确定了硫酸化位点的几个显着特征，包括：1）丰富的酸性氨基酸残基，2）缺乏碱性残基，3）低亲水性，4）缺乏邻近的半胱氨酸残基，5）缺乏扩展的二级结构。提出了根据蛋白质的氨基酸序列预测可能的硫酸化位点的规则。
A wide variety of secretory proteins have recently been found to undergo post-translational sulfation of specific tyrosine residues. Here, amino acid sequences surrounding known sulfation sites in proteins are analysed in order to identify factors which determine the specificity of sulfation. Several distinctive features of sulfation sites are identified, including: 1) abundance of acidic amino acid residues, 2) lack of basic residues, 3) low hydropathy, 4) absence of neighboring cysteine residues, 5) lack of extended secondary structure. Rules are proposed for predicting likely sites of sulfation based on the amino acid sequence of a protein.