Antidepressants and the muscarinic acetylcholine receptor.
Antidepressants and the muscarinic acetylcholine receptor.
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抗抑郁药和毒蕈碱乙酰胆碱受体。
DOI：
10.1001/archpsyc.1977.01770140126014
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发表时间：
1977
影响因子：
--
通讯作者：
H. Yamamura
中科院分区：
文献类型：
--
作者：
SolomonH Snyder;H. Yamamura
已经评估了几种三环类抗抑郁药与脑和肠的毒蕈碱乙酰胆碱受体结合的效力。盐酸阿米替林的效力约为盐酸丙咪嗪的10倍。二甲基化的药物比单甲基化的药物更有效。三环类抗抑郁药的相对抗胆碱能活性对其在可能受到抗胆碱能作用不良影响的患者中的使用具有影响。
Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.