Pattern and determinants of antiretroviral drug adherence among Nigerian pregnant women.
Pattern and determinants of antiretroviral drug adherence among Nigerian pregnant women.
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DOI：
10.1155/2012/851810
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发表时间：
2012
影响因子：
3.2
通讯作者：
Ezechi OC
中科院分区：
文献类型：
--
作者：
Ekama SO;Herbertson EC;Addeh EJ;Gab-Okafor CV;Onwujekwe DI;Tayo F;Ezechi OC
背景资料。对抗逆转录病毒药物的高度依从性的需要仍然是从怀孕期间使用抗逆转录病毒药物获得最大好处的主要障碍。这项研究旨在确定妊娠期间的依从性水平，并确定影响依从性的因素。方法。这是一项使用半结构问卷的横断面研究。使用双变量和多元Logistic回归模型来确定与妊娠期间良好的药物依从性独立相关的因素。结果。在受访的170名妇女中，137人(80.6%)通过3天的回想达到了≥依从性95%的水平。保护未出生的孩子的愿望是良好坚持的最大动机(51.8%)。害怕被确认为HIV阳性(63.6%)是不遵守的最常见原因。在双变量分析中，婚姻状况、艾滋病毒状况的披露、良好的抗逆转录病毒治疗知识以及有治疗支持者被发现与良好的依从性显著相关。然而，在控制了混杂因素后，只有艾滋病毒状况披露和拥有治疗伙伴保持了良好的依从性。结论。披露艾滋病毒状况和获得治疗支持与良好的遵从性有关。母亲保护孩子的愿望是坚持的最大动机。
Background. The need for a high level of adherence to antiretroviral drugs has remained a major hurdle to achieving maximal benefit from its use in pregnancy. This study was designed to determine the level of adherence and identify factors that influence adherence during pregnancy. Method. This is a cross-sectional study utilizing a semistructured questionnaire. Bivariate and multiple logistic regression models were used to determine factors independently associated with good drug adherence during pregnancy. Result. 137 (80.6%) of the interviewed 170 women achieved adherence level of ≥95% using 3 day recall. The desire to protect the unborn child was the greatest motivation (51.8%) for good adherence. Fear of being identified as HIV positive (63.6%) was the most common reason for nonadherence. Marital status, disclosure of HIV status, good knowledge of ART, and having a treatment supporter were found to be significantly associated with good adherence at bivariate analysis. However, after controlling for confounders, only HIV status disclosure and having a treatment partner retained their association with good adherence. Conclusion. Disclosure of HIV status and having treatment support are associated with good adherence. Maternal desire to protect the child was the greatest motivator for adherence.