Vision-Related Quality of Life in Patients with Ocular Graft-versus-Host Disease.
Vision-Related Quality of Life in Patients with Ocular Graft-versus-Host Disease.
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DOI：
10.1016/j.ophtha.2015.04.011
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发表时间：
2015-08
期刊：
影响因子：
13.7
通讯作者：
Dana R
中科院分区：
文献类型：
--
作者：
Saboo US;Amparo F;Abud TB;Schaumberg DA;Dana R
评估眼部移植物抗宿主病（GVHD）患者的视力相关生活质量。前瞻性研究。84例慢性眼部移植物抗宿主病患者，我们用25项国家眼科研究所视觉功能问卷（NEI-VFQ-25）评估视觉相关的生活质量。采用眼表疾病指数（OSDI）和干眼症状评估（桑德）问卷对眼部GVHD的症状进行评估。我们用NEI-VFQ-25评估了视力相关的生活质量，并比较了眼部GVHD患者与健康人群的评分。在眼部GVHD人群中，我们还评估了NEI-VFQ-25与通过OSDI和桑德问卷、年龄、病程、最佳矫正视力、角膜荧光素染色、泪膜破裂时间和Schirmer试验测量的干眼症状之间的相关性。眼部GVHD患者的平均综合NEI-VFQ-25评分为76.5 ± 17。与健康受试者相比，眼部GVHD患者报告了除色觉（P = 0.11）外的所有NEI-VFQ-25子量表的评分降低（每个P < 0.001）。NEI-VFQ-25综合评分与OSDI（R =-0.81，P < 0.001）、桑德（R =-0.56，P < 0.001）、角膜荧光素染色（R =-0.36，P = 0.001）和最佳矫正视力（R =-0.30，P = 0.004）显著相关。患有眼部GVHD的患者经历了视觉相关生活质量的可测量损害。这项研究强调了眼部GVHD对视觉相关生活质量的影响，因此强调了全面诊断和治疗这种疾病的重要性。
To assess the vision-related quality of life in a cohort of patients with ocular graft-versus-host disease (GVHD). Prospective study. Eighty-four patients diagnosed with chronic ocular GVHD We assessed the vision-related quality of life with the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25). The symptoms of ocular GVHD were assessed using the Ocular Surface Disease Index (OSDI) and Symptom Assessment in Dry Eye (SANDE) questionnaires. We assessed vision-related quality of life with NEI-VFQ-25 and compared the scores obtained from patients with ocular GVHD to those from a healthy population. In the ocular GVHD population, we also evaluated the associations between the NEI-VFQ-25 and dry eye symptoms measured by OSDI and SANDE questionnaires, age, duration of disease, best-corrected visual acuity, corneal fluorescein staining, tear break-up time, and Schirmer test. The mean composite NEI-VFQ-25 score in patients with ocular GVHD was 76.5 ± 17. Compared to healthy subjects, ocular GVHD patients reported reduced scores on all NEI-VFQ-25 subscales (each P < 0.001) with exception of color vision (P = 0.11). The NEI-VFQ-25 composite scores significantly correlated with OSDI (R = −0.81, P < 0.001), SANDE (R = −0.56, P < 0.001), corneal fluorescein staining (R = −0.36, P = 0.001) and best-corrected visual acuity (R = −0.30, P = 0.004). Patients with ocular GVHD experience measurable impairment of vision-related quality of life. This study highlights the impact of ocular GVHD on the vision-related quality of life, and hence the importance of comprehensive diagnosis and treatment of this condition.