Nucleotide variation in ATG4A and susceptibility to cervical cancer in Southwestern Chinese women.
Nucleotide variation in ATG4A and susceptibility to cervical cancer in Southwestern Chinese women.
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中国西南地区女性ATG4A核苷酸变异与宫颈癌易感性
DOI：
10.3892/ol.2017.7663
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发表时间：
2018-03
期刊：
影响因子：
2.9
通讯作者：
Chen WX
中科院分区：
文献类型：
--
作者：
Mao JJ;Wu LX;Wang W;Ye YY;Yang J;Chen H;Yang QF;Zhang XY;Wang B;Chen WX
早期检测人乳头状瘤病毒(HPV)对宫颈癌的临床诊断具有重要意义。然而，到目前为止，宫颈癌的发病机制仍不清楚。自噬是一个动态过程，有助于维持细胞内环境的稳定。在这里，我们调查自噬基因的变异是否会影响宫颈癌的发生。在本研究中，我们的研究结果表明，自噬相关蛋白4(ATG4)的单核苷酸多态性(SNPs)，包括rs4036579、rs5973822、rs807181、rs807182和rs807183，与宫颈癌风险密切相关。此外，分层分析表明，纯合子变异基因型可以降低宫颈癌的风险，在研究HPV在宫颈癌中的作用时应该考虑到这一点。本研究旨在探讨西南中国地区人群HPV感染是否与ATG4A单核苷酸多态有关。在癌症病例和健康对照受试者的样本中，评估了单个SNP和SNP-SNP相互作用与HPV的关联。在病例组和对照组中，rs807181和rs807183的相互作用与HPV感染相关(联合P值分别为2.00×10−3和3.22×10−2)。这一结果表明，ATG4A SNP的相互作用可能影响西南中国地区人群的HPV感染。值得注意的是，自噬基因ATG4A可能与宫颈癌有关。
Early detection of human papillomavirus (HPV) is important for the clinical diagnosis of cervical cancer. However, to date, the pathogenesis of cervical cancer is still unclear. Autophagy is a dynamic process that contributes to the maintenance of cellular homeostasis. Here, we investigate whether variants of autophagy genes affect the occurrence of cervical cancer. In this study, our results indicate that single nucleotide polymorphisms (SNPs) of autophagy-related protein 4 (ATG4), including rs4036579, rs5973822, rs807181, rs807182 and rs807183, have a significant relationship with cervical cancer risk. Furthermore, stratified analysis suggests that the homozygous variant genotype could decrease the risk of cervical cancer and should be considered when investigating the role of HPV in cervical cancer. We aim to investigate whether SNPs of ATG4A contribute to HPV infection in the population of Southwestern China. The association of both single SNPs and SNP-SNP interactions with HPV was evaluated in a sample of cancer cases and healthy control subjects. The interaction of rs807181 and rs807183 was associated with HPV infection in case and control subjects (combined P=2.00×10−3 and 3.22×10−2, respectively). This result showed that ATG4A SNP interactions may affect HPV infection in the population of Southwestern China. Notably, the autophagy gene ATG4A may contribute to cervical cancer.
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