CHARACTERISTICS AND UTILIZATION OF ANTIBODY MEASUREMENTS IN CLINICAL-STUDIES OF PERIODONTAL-DISEASE
CHARACTERISTICS AND UTILIZATION OF ANTIBODY MEASUREMENTS IN CLINICAL-STUDIES OF PERIODONTAL-DISEASE
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DOI：
10.1902/jop.1992.63.12s.1110
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发表时间：
1992-12-01
影响因子：
4.3
通讯作者：
STEFFEN, MJ
中科院分区：
文献类型：
--
作者：
EBERSOLE, JL;CAPPELLI, D;STEFFEN, MJ
对感染的免疫应答的检测和定量长期以来一直被用作医疗感染的诊断工具。最近，越来越多的证据支持，积极的，特异性抗体反应的选定成员的龈下微生物在牙周炎患者注意到。本报告描述了这种抗体的各种特异性，因为它们与牙周炎的分类和预后有关。血清抗体的功能方面已经受到越来越多的审查，以更好地了解在牙周组织中起作用的潜在免疫机制。可获得描述抗体的调理作用潜力、补体固定能力、阻断功能和抗毒性能力的数据。特异性抗体水平的纵向变化与感染有关，并伴随着龈下菌斑中特定微生物负荷的变化。因此，这些抗体的变化可能是改变宿主-寄生虫相互作用的有用指标，预示着疾病的活跃发作。最后，设计研究以检查抗体反映治疗对疾病的影响的能力。结果表明，特异性抗体水平随着机械、抗菌和抗炎处理而变化。本报告中描述的研究结果表明，血清抗体的水平和特异性的评价可以是一个有益的辅助设计和实施临床研究描绘的开始，进展和牙周炎的治疗。
THE DETECTION AND QUANTITATION OF IMMUNE RESPONSEs to infections have long been used as a diagnostic tool in medical infections. Recently, increasing evidence has supported that active, specific antibody responses to selected members of the subgingival microbiota are noted in periodontitis patients. This report describes the various specificities of this antibody as they relate to periodontitis classification and prognosis. The functional aspects of the serum antibody have come under increasing scrutiny to understand better the potential immunologic mechanisms acting in the periodontium. Data are available that describe opsonizing potential, complement fixing ability, blocking functions, and anti-toxic capacity for the antibody. Longitudinal alterations in specific antibody levels are shown to relate to infection and accompany changes in the burden of a specific microorganism in the subgingival plaque. Thus, these antibody changes could be useful indicators of altered host-parasite interactions that presage a disease-active episode. Finally, studies were designed to examine the ability of antibody to reflect the effects of treatment on the disease. The results indicated that specific antibody levels change with mechanical, antimicrobial, and anti-inflammatory treatments. The findings described in this report suggest that evaluation of the level and specificity of serum antibody can be a beneficial adjunct in designing and implementing clinical studies delineating the initiation, progression, and treatment of periodontitis.