Nanoparticle-mediated gene delivery to tumour neovasculature
Nanoparticle-mediated gene delivery to tumour neovasculature
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DOI：
10.1016/s1471-4914(02)00004-7
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发表时间：
2003-01-01
影响因子：
13.6
通讯作者：
Hodivala-Dilke, K
中科院分区：
文献类型：
--
作者：
Reynolds, AR;Moghimi, SM;Hodivala-Dilke, K
α(V)β(3)整合素是抗血管生成治疗的潜在药理靶点。最近的一份报告描述了使用α(V)β(3)靶向纳米颗粒选择性地将基因输送到肿瘤血管系统。这导致了几个实验性小鼠肿瘤模型中肿瘤的实质性消退。因此，这种方法在治疗人类癌症方面具有巨大的潜力。
The alpha(v)beta(3) integrin is a potential pharmacological target for anti-angiogenic therapy. A recent report describes the use of alpha(v)beta(3)-targeted nanoparticles to deliver a gene to tumour vasculature selectively. This resulted in substantial tumour regression in several experimental mouse tumour models. Hence, this approach has great potential for the treatment of human cancer.