AMASTATIN POTENTIATES THE BEHAVIORAL-EFFECTS OF VASOPRESSIN AND OXYTOCIN IN MICE
AMASTATIN POTENTIATES THE BEHAVIORAL-EFFECTS OF VASOPRESSIN AND OXYTOCIN IN MICE
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DOI：
10.1016/0196-9781(84)90083-4
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发表时间：
1984-01-01
期刊：
影响因子：
3
通讯作者：
SIMMONS, WH
中科院分区：
文献类型：
--
作者：
MEISENBERG, G;SIMMONS, WH
侧脑室注射加压素和催产素引起小鼠行为兴奋。这种作用是短暂的，表明肽在大脑中迅速失活。共同注射μ g量的amastatin（一种氨肽酶抑制剂）延长了加压素和催产素的作用。Amastatin本身不诱导大的加压素样行为效应，也不显著增强1-脱氨基[1，6-二卡巴，8-精氨酸]加压素（Asu-AVP）（一种缺乏N-末端氨基的类似物）的作用。Asu-AVP的作用，而不是加压素，增强了phosphoramidon，中性金属内肽酶（脑啡肽酶A）的抑制剂。加压素和催产素在侧脑室注射后主要通过氨肽酶的作用而失活。
Vasopressin and oxytocin cause behavioral excitation after intracerebroventricular injection in mice. This effect is short-lasting, suggesting that the peptides are rapidly inactivated in the brain. Co-injection of .mu.g amounts of amastatin, an aminopeptidase inhibitor, prolonged the effect of both vasopressin and oxytocin. Amastatin did not induce large vasopressin-like behavioral effects by itself, nor did it significantly potentiate the action of 1-deamino[1,6-dicarba, 8-arginine]vasopressin (Asu-AVP), an analog that lacks the N-terminal amino group. The effect of Asu-AVP, but not that of vasopressin, was potentiated by phosphoramidon, an inhibitor of neutral metalloendopeptidase (enkephalinase A). Vasopressin and oxytocin are apparently inactivated mainly by aminopeptidase action following intracerebroventricular injection.