Heterozygous VMAT2 knockout mice display prolonged QT intervals: possible contributions to sudden death
Heterozygous VMAT2 knockout mice display prolonged QT intervals: possible contributions to sudden death
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DOI：
10.1016/s0169-328x(99)00194-1
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发表时间：
1999-08-25
期刊：
影响因子：
--
通讯作者：
Uhl, GR
中科院分区：
文献类型：
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作者：
Itokawa, K;Sora, I;Uhl, GR
囊泡单胺转运蛋白（VMAT2）表达水平为野生型一半的杂合敲除（KO）小鼠可在中年突然死亡。为了寻找这种猝死的机制，我们检查了从自由活动的杂合子和野生型交配小鼠中遥测到的心电图（ECG）数据。这两种菌株小鼠的许多心电图参数无法区分。然而，杂合子小鼠表现出延长的QT间期。这些发现为这些动物致死性心律失常的易感性差异提供了可能的贡献，并为人类对心律失常易感性的个体间差异提供了一个候选基因。(C) 1999 Elsevier Science B.V.版权所有
Heterozygous knockout (KO) mice with half of wild-type levels of expression of the vesicular monoamine transporter (VMAT2) can suddenly die in midlife. To seek mechanisms for this sudden death, we have examined electrocardiogram (ECG) data telemetered from freely-moving heterozygote and wild-type littermate mice. Many ECG parameters were indistinguishable in mice of these two strains. However, heterozygous mice displayed prolonged QT intervals. These findings provide likely contributions to differences in vulnerability to lethal arrhythmias in these animals, and a candidate gene for contributions to human interindividual differences in vulnerability to cardiac arrhythmias. (C) 1999 Elsevier Science B.V. All rights reserved.