What Is the Test-Retest Reliability of Common Task-Functional MRI Measures? New Empirical Evidence and a Meta-Analysis
What Is the Test-Retest Reliability of Common Task-Functional MRI Measures? New Empirical Evidence and a Meta-Analysis
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DOI：
10.1177/0956797620916786
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发表时间：
2020-06-03
影响因子：
8.2
通讯作者：
Hariri, Ahmad R.
中科院分区：
文献类型：
--
作者：
Elliott, Maxwell L.;Knodt, Annchen R.;Hariri, Ahmad R.
确定疾病风险的大脑生物标志物是神经科学中日益重要的一个问题。识别有意义的生物标志物的能力受到测量可靠性的限制;不可靠的测量不适合预测临床结果。使用任务功能磁共振成像（fMRI）测量大脑活动是生物标志物开发的主要焦点;然而，任务功能磁共振成像的可靠性尚未得到系统评估。我们提出了收敛的证据表明任务功能磁共振成像测量的可靠性差。首先，90个实验（N = 1,008）的荟萃分析显示整体可靠性较差-平均组内相关系数（ICC）= 0.397。其次，在人类连接组计划（N = 45）和达尼丁研究（N = 20）收集的11个常见功能磁共振成像任务中，先验感兴趣区域的活动的重测信度很差（ICC = 0.067 - 0.485）。总的来说，这些研究结果表明，共同的任务功能磁共振成像措施目前不适合大脑生物标志物的发现或个体差异的研究。我们回顾了这种情况是如何出现的，并强调了提高任务功能磁共振成像可靠性的途径。
Identifying brain biomarkers of disease risk is a growing priority in neuroscience. The ability to identify meaningful biomarkers is limited by measurement reliability; unreliable measures are unsuitable for predicting clinical outcomes. Measuring brain activity using task functional MRI (fMRI) is a major focus of biomarker development; however, the reliability of task fMRI has not been systematically evaluated. We present converging evidence demonstrating poor reliability of task-fMRI measures. First, a meta-analysis of 90 experiments (N = 1,008) revealed poor overall reliability-mean intraclass correlation coefficient (ICC) = .397. Second, the test-retest reliabilities of activity in a priori regions of interest across 11 common fMRI tasks collected by the Human Connectome Project (N = 45) and the Dunedin Study (N = 20) were poor (ICCs = .067-.485). Collectively, these findings demonstrate that common task-fMRI measures are not currently suitable for brain biomarker discovery or for individual-differences research. We review how this state of affairs came to be and highlight avenues for improving task-fMRI reliability.