Hochu-ekki-to combined with interferon-gamma moderately enhances daily activity of chronic fatigue syndrome mice by increasing NK cell activity, but not neuroprotection
Hochu-ekki-to combined with interferon-gamma moderately enhances daily activity of chronic fatigue syndrome mice by increasing NK cell activity, but not neuroprotection
复制标题
DOI：
10.1080/08923970802391525
复制
发表时间：
2009-06-01
影响因子：
3.3
通讯作者：
Yoshizaki, Fumihiko
中科院分区：
文献类型：
--
作者：
Chen, Rui;Moriya, Junji;Yoshizaki, Fumihiko
本研究的目的是评估Hochu-ekki-to（TJ-41）与干扰素-γ（IFN-γ）组合对慢性疲劳综合征（CFS）小鼠模型的日常活动、免疫和神经系统改变的有益效果。每2周重复注射牛种布氏杆菌抗原6次诱发CFS。TJ-41单用和TJ-41联合IFN-γ均能增加CFS小鼠的跑步活动和胸腺重量，但联合治疗组胸腺皮质增厚，NK细胞活性升高。两个治疗组的脑萎缩和海马脑源性神经营养因子和Bcl-2 mRNA表达水平的降低均无明显改善。我们的研究结果表明，TJ-41与IFN γ结合可能具有保护作用的显着减少的活动在CFS模型通过正常化的主机免疫反应，但没有神经保护。
The purpose of this study was to evaluate the beneficial effect of Hochu-ekki-to (TJ-41) combined with interferon-gamma (IFN gamma) on daily activity, immunological and neurological alternation in a mouse model of chronic fatigue syndrome (CFS). CFS was induced by 6 times of repeated injection of Brucella abortus antigen every 2 weeks. Both single TJ-41 and TJ-41 combined with IFN gamma increased running activity and thymus weight of CFS mice, while thicker thymic cortex together with elevation of natural killer cell activity was only found in the combined treatment group. No significant improvement was observed in the atrophic brain and decreased expression level of brain-derived neurotrophic factor and Bcl-2 mRNA in hippocampus in both treatment groups. Our results suggest that TJ-41 combined with IFN gamma might have a protective effect on the marked reduction in the activity in a model of CFS via normalization of host immune responses, but not neuroprotection.